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1. (WO2007008479) TREATMENT OF PATIENTS WITH CANCER USING A CALICHEAMICIN-ANTIBODY CONJUGATE IN COMBINATION WITH ZOSUQUIDAR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008479 International Application No.: PCT/US2006/025909
Publication Date: 18.01.2007 International Filing Date: 30.06.2006
IPC:
A61K 39/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
KANISA PHARMACEUTICALS, INC. [US/US]; 12264 El Camino Real, Suite 300 San Diego, California 92130, US (AllExceptUS)
SIKIC, Branimir [US/US]; US (UsOnly)
HOTH, Daniel [US/US]; US (UsOnly)
SOCKS, David [US/US]; US (UsOnly)
GLENN, Scott [US/US]; US (UsOnly)
MARCELLETTI, John [US/US]; US (UsOnly)
WALSH, Michael, J. [US/US]; US (UsOnly)
MULTANI, Pratik, S. [US/US]; US (UsOnly)
Inventors:
SIKIC, Branimir; US
HOTH, Daniel; US
SOCKS, David; US
GLENN, Scott; US
MARCELLETTI, John; US
WALSH, Michael, J.; US
MULTANI, Pratik, S.; US
Agent:
HART, Daniel; Knobbe Martens Olson & Bear LLP 2040 Main Street, 14th Floor Irvine, California 92614, US
Priority Data:
11/416,83303.05.2006US
11/416,99203.05.2006US
60/696,75606.07.2005US
Title (EN) TREATMENT OF PATIENTS WITH CANCER USING A CALICHEAMICIN-ANTIBODY CONJUGATE IN COMBINATION WITH ZOSUQUIDAR
(FR) TRAITEMENT DE PATIENTS ATTEINTS DE CANCER A L'AIDE D'UN CONJUGUE DE CALICHEAMICINE ET D'ANTICORPS EN COMBINAISON AVEC DU ZOSUQUIDAR
Abstract:
(EN) The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar and a calicheamicin-antibody conjugate, such as Mylotarg. The invention is also directed to pharmaceutical formulations comprising zosuquidar and calicheamicin-antibody conjugates. The formulations are particularly effective in treating relapsed Acute Myelogenous Leukemia (AML) and metastatic breast cancer.
(FR) La présente invention concerne une méthode de traitement de patients atteints de tumeurs solides, de leucémies, et autres tumeurs malignes à l'aide d'une combinaison de zosuquidar et d'un conjugué de calichéamicine et d'anticorps, tel que le Mylotarg. L'invention concerne également des compositions pharmaceutiques comprenant du zosuquidar et des conjugués de calichéamicine et d'anticorps. Lesdites préparations sont particulièrement efficaces pour le traitement de la leucémie myélogène aiguë (LMA) récidivante et le cancer du sein métastatique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2008/000225KR1020080030659EP1898946JP2009500416CN101257921CA2614321
AU2006269481IN547/KOLNP/2008