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1. (WO2007008377) OOCYTES DERIVED FROM OVARIAN CULTURE INITIALLY CONTAINING NO OOCYTES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008377 International Application No.: PCT/US2006/024617
Publication Date: 18.01.2007 International Filing Date: 23.06.2006
IPC:
C12N 5/00 (2006.01) ,C12N 5/02 (2006.01) ,C12N 5/075 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
02
Propagation of single cells or cells in suspension; Maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
075
Oocytes; Oogonia
Applicants:
UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION [US/US]; 1534 White Avenue, Suite 403 Knoxville, TN 37996-1527, US (AllExceptUS)
BUKOVSKY, Antonin [CZ/US]; US (UsOnly)
CAUDLE, Michael, R. [US/US]; US (UsOnly)
Inventors:
BUKOVSKY, Antonin; US
CAUDLE, Michael, R.; US
Agent:
EISENBERG, Howard; 1220 Limberlost Lane Gladwyne, PA 19035, US
Priority Data:
60/696,95206.07.2005US
Title (EN) OOCYTES DERIVED FROM OVARIAN CULTURE INITIALLY CONTAINING NO OOCYTES
(FR) OVOCYTES DERIVES D'UNE CULTURE OVARIENNE NE CONTENANT PAS D'OVOCYTES INITIALEMENT
Abstract:
(EN) Ovarian germ-line-competent embryonic stem cells (GLC- ESC) are cultured, either in the presence or absence of a compound having estrogenic activity. The GLC-ESC are either collected prior to specific commitment or are permitted to remain in the culture medium for a time sufficient to develop into oocytes, and the oocytes may be fertilized by adding sperm to the culture medium. The fertilized oocytes may be permitted to develop into embryos, which may be transferred into the uterus of an adult human female or frozen for later use. The invention provides a method for obtaining by in vitro fertilization an embryo that is genetically related to a human female who is not producing oocytes .
(FR) Selon l'invention, on cultive des cellules souches embryonnaires ovariennes à compétence germinale (GLC- ESC), en présence ou en l'absence d'un composé à activité oestrogénique. On collecte les cellules GLC-ESC avant leur détermination spécifique ou on peut les maintenir dans le milieu de culture pendant une durée suffisante pour qu'elles se développent en ovocytes, les ovocytes pouvant être fertilisés par ajout de sperme dans le milieu de culture. On peut laisser les ovocytes fertilisés se développer en embryons que l'on peut transférer dans l'utérus d'une femme adulte ou que l'on peut congeler pour une utilisation ultérieure. Ainsi, l'invention fournit un procédé permettant d'obtenir, par fécondation in vitro, un embryon qui est génétiquement lié à une femme ne produisant pas d'ovocytes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)