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1. (WO2007008376) USE OF ONE OR MORE METAL CARRIERS TO SELECTIVELY KILL MAMMALIAN CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008376 International Application No.: PCT/US2006/024608
Publication Date: 18.01.2007 International Filing Date: 23.06.2006
IPC:
A61K 38/02 (2006.01) ,C07C 333/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
02
Peptides of undefined number of amino acids; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
333
Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
14
Dithiocarbamic acids; Derivatives thereof
Applicants:
CANCURE LABORATORIES, LLC [US/US]; 404 20th Street SW Austin, Minnesota 55912, US (AllExceptUS)
KISS, Zoltan [HU/US]; US (UsOnly)
Inventors:
KISS, Zoltan; US
Agent:
D'SOUZA, Tanya_; 90 South Seventh Street 2200 Wells Fargo Center Minneapolis, Minnesota 55402-3901, US
Priority Data:
60/697,18107.07.2005US
Title (EN) USE OF ONE OR MORE METAL CARRIERS TO SELECTIVELY KILL MAMMALIAN CELLS
(FR) UTILISATIONS VECTEURS METALLIQUES POUR TUER LES CELLULES MAMMIFERES DE MANIERE SELECTIVE
Abstract:
(EN) Compositions and methods for decreasing the viability of cells, particularly aberrant non-healthy cells, and most particularly cancer cells, are disclosed. The primary agent that causes cell death is a toxic metal atom or ion. Embodiments of the invention provide compositions and methods to ensure that the toxic metal is directed to the desired cell or tissue. In one embodiment, the metal is bound to a sulfur-rich peptide or protein carrier containing a targeting moiety. Such metal-protein complex is targeted to the selected cells or tissues to enrich the cell or tissue site with the metal-containing peptide or protein molecules followed by administering a dithiocarbonyl which carries the metal from the protein inside the cells to induce cell death.
(FR) des compositions et des procédés de diminution de la viabilité de cellules, notamment de cellules malsaines aberrantes, et plus particulièrement de cellules cancéreuses, font intervenir un agent principal causant la mort cellulaire qui est un atome ou un ion métallique toxique. Selon des variantes, les compositions et procédés garantissent que le métal toxique est dirigé sur la cellule ou un tissu souhaité(e). selon une variante, le métal est lié à un vecteur peptidique ou protéique riche en souffre contenant une fraction de ciblage. Un tel complexe métal-protéine est ciblé sur les cellules ou tissus sélectionné(e)s pour enrichir le site cellulaire ou tissulaire avec les molécules peptidiques ou protéiniques contenant le métal avant d'administrer un dithiocarbonyle portant le métal de la protéine vers l'intérieur des cellules afin d'induire la mort cellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1901762