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1. (WO2007008338) EGFR INHIBITORS PROMOTE AXON REGENERATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008338 International Application No.: PCT/US2006/023431
Publication Date: 18.01.2007 International Filing Date: 13.06.2006
IPC:
C07K 14/705 (2006.01) ,C07K 14/485 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
485
Epidermal growth factor (EGF) (urogastrone)
Applicants:
CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 300 Longwood Avenue Boston, MA 02115, US (AllExceptUS)
HE, Zhigang [CN/US]; US (UsOnly)
KOPRIVICA, Vuk [US/US]; US (UsOnly)
Inventors:
HE, Zhigang; US
KOPRIVICA, Vuk; US
Agent:
OSMAN, Richard; 242 Avenida Vista Del Oceano San Clemente, CA 92672, US
Priority Data:
11/180,07012.07.2005US
Title (EN) EGFR INHIBITORS PROMOTE AXON REGENERATION
(FR) INHIBITEURS EGFR ACTIVANT LA REGENERATION DE L'AXONE
Abstract:
(EN) Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
(FR) L'invention concerne des compositions et des méthodes d'activation d'une régénération neurale chez un patient présentant une lésion dans une neurone mature du SNC. La méthode consiste à placer la neurone au contact d'un inhibiteur EGFR pouvant activer la régénération de la neurone.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1902068JP2009501221CA2610830AU2006269616