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1. (WO2007008252) GENETIC AND EPIGENETIC ALTERATIONS IN THE DIAGNOSIS AND TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008252 International Application No.: PCT/US2005/046069
Publication Date: 18.01.2007 International Filing Date: 20.12.2005
IPC:
G01N 33/574 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEMS OF HIGHER EDUCATION [US/US]; Office of Technology Temple University Philadelphia, PA 19122-6099, US (AllExceptUS)
GIORDANO, Antonio [US/US]; US (UsOnly)
Inventors:
GIORDANO, Antonio; US
Agent:
CARANGO, Paul ; DLA Piper Rudnick Gray Cary US LLP Suite 4900 1650 Market Street Philadelphia, PA 19103, US
Priority Data:
60/698,72112.07.2005US
Title (EN) GENETIC AND EPIGENETIC ALTERATIONS IN THE DIAGNOSIS AND TREATMENT OF CANCER
(FR) MODIFICATIONS GÉNÉTIQUES ET ÉPIGÉNÉTIQUES DANS LE DIAGNOSTIC ET LE TRAITEMENT DU CANCER
Abstract:
(EN) Methylation of DNA in regions involved in transcriptional regulation can induce the binding of ICBP90 and the subsequent formation of multiprotein complexes which alter gene transcription. DNA methylation in tumor suppressor genes, or in other genes which are involved in mitigating tumorigenesis, can induce binding of ICBP90 to those genes. Bound ICBP90 can interact with a pRb2/p130 regulatory complexes to remodel chromatin and inhibit transcription of the gene. DNA methyltransferases, ICBP90, and the proteins comprising the pRb2/p130 complex are therefore therapeutic targets for the treatment of cancer. Abnormalities in these proteins can also be markers of cancerous or precancerous conditions.
(FR) Cette invention concerne la méthylation de l’ADN dans des régions concernées par la régulation de la transcription pouvant induire la liaison de l’ICBP90 et la formation ultérieure de complexes multiprotéines qui modifient la transcription génique. La méthylation de l’ADN peut, dans les gènes suppresseurs de tumeurs ou dans les autres gènes impliqués dans la réduction de la tumorigenèse, induire la liaison de l’ICBP90 à ces gènes. L’ICBP90 ainsi lié peut interagir avec des complexes régulateurs de pRb2/p130 pour remodeler la chromatine et inhiber la transcription du gène. Les ADN-méthyltransférases, l’ICBP90, et les protéines comprenant le complexe pRb2/p130 constituent dès lors des objectifs thérapeutiques pour le traitement du cancer. Les anomalies de ces protéines peuvent également constituer des marqueurs des états cancéreux ou précancéreux.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1907855JP2009501024US20090270479