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1. WO2007008200 - WORTMANNIN ANALOGS AND METHODS OF USING SAME IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS

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Claims

We claim:

1. A method of treating cancer comprising administering to a subject a pharmaceutically effective amount of a compound comprising



wherein Y is a heteroatom and Rl or R2 is an unsaturated alkyl, non-linear alkyl, or substituted alkyl respectively, and a chemotherapeutic agent.

2. The method of claim 1, wherein said Rl or R2 is a disubstituted alkyl.

3. The method of claim 1, wherein said chemotherapeutic agent is selected from the group consisting of a cytotoxic agent and a anti-tumor targeting agent.

4. The method of claim 2, wherein said cytotoxic agent is selected from the group consisting of gemcitabine, paclitaxel, and cisplatin.

5. The method of claim 2, wherein said anti -tumor targeting agent is selected from the group consisting of gefitinib, erlotinib, trastuzumab, cetuximab and bevacizumab.

6. The method of claim 1, wherein said compound is:



6. The method of claim 1, wherein said compound is:


7. The method of claim 1, wherein said compound is:


8. The method of claim 1, wherein said compound is administered orally.

9. The method of claim 1, wherein said compound is administered intravenously.

10. The method of claim 1, wherein said compound is PX-866 and said chemotherapeutic agent is gefitinib.

11. The method of claim 1, wherein said compound is PX-866 and said chemotherapeutic

agent is bevacizumab.

12. The method of claim 1, wherein said compound is PX-867 and said chemotherapeutic

agent is gefitinib.

13. The method of claim 1, wherein said compound is PX-867 and said chemotherapeutic agent is bevacizumab.

14. The method of claim 1, further comprising administering an antihyperglycemic agent.

15. A composition comprising a compound of the formula


wherein Y is a heteroatom and Rl or R2 is an unsaturated alkyl, non-linear alkyl, or substituted alkyl respectively, and a chemotherapeutic agent.