WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007008016) A COMPOUND COMPRISING PRODIGIOSIN ISOLATED FROM SERRATIA MARCESCENCE B-1231 KCTC 0386BP FOR PROVENTION AND TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/008016    International Application No.:    PCT/KR2006/002700
Publication Date: 18.01.2007 International Filing Date: 10.07.2006
IPC:
A61K 31/4025 (2006.01), A61P 37/06 (2006.01)
Applicants: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 52, Eoeun-dong, Yuseong-gu, Daejeon 305-333 (KR) (For All Designated States Except US).
KIM, Hwan Mook [KR/KR]; (KR) (For US Only).
HAN, Sang Bae [KR/KR]; (KR) (For US Only).
LEE, Chang Woo [KR/KR]; (KR) (For US Only).
LEE, Ki Hoon [KR/KR]; (KR) (For US Only).
PARK, Sung Kyu [KR/KR]; (KR) (For US Only).
LEE, Ki Ho [KR/KR]; (KR) (For US Only).
KANG, Jong Soon [KR/KR]; (KR) (For US Only).
YOON, Won Kee [KR/KR]; (KR) (For US Only).
KIM, Young Kook [KR/KR]; (KR) (For US Only)
Inventors: KIM, Hwan Mook; (KR).
HAN, Sang Bae; (KR).
LEE, Chang Woo; (KR).
LEE, Ki Hoon; (KR).
PARK, Sung Kyu; (KR).
LEE, Ki Ho; (KR).
KANG, Jong Soon; (KR).
YOON, Won Kee; (KR).
KIM, Young Kook; (KR)
Agent: LEE, Duck Rog; Yeil Patent & Trademark International, Yeilpat Bldg., 669-17 Yorksam-dong, Kangnam-ku, Seoul 135-915 (KR)
Priority Data:
10-2005-0062287 11.07.2005 KR
Title (EN) A COMPOUND COMPRISING PRODIGIOSIN ISOLATED FROM SERRATIA MARCESCENCE B-1231 KCTC 0386BP FOR PROVENTION AND TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE
(FR) COMPOSE COMPRENANT DE LA PRODIGIOSINE ISOLEE A PARTIR DE SERRATIA MARCESCENS B-1231 KCTC 0386BP POUR LA PREVENTION ET LE TRAITEMENT DES REACTIONS AIGUES DU GREFFON CONTRE L'HOTE
Abstract: front page image
(EN)This invention relates to a composition for the prevention and treatment of acute graft-versus-host disease comprising prodigiosin isolated from Serratia marcescence B- 1231 KCTC 0386BP, as an effective ingredient. The prodigiosin is immunosuppressive by selectively suppressing the proliferation of T-cells through the suppression of the expression of IL-2 receptors, which is needed for the activation of T-cells. Prodigiosin can be used either alone or in conjunction with cyclosporin A for greater effect, since the two substances have different mode of actions. These make prodigiosin effective for the prevention and treatment of acute graft-versus-host disease.
(FR)L'invention se rapporte à une composition permettant la prévention et le traitement de la réaction aiguë du greffon contre l'hôte, contenant en tant que principe actif de la prodigiosine isolée à partir de Serratia marcescens B-1231 KCTC 0386BP. La prodigiosine exerce une activité immunosuppressive en bloquant sélectivement l'expression des récepteurs de l'IL-2 qui est nécessaire à l'activation des lymphocytes T. La progidiosine peut être utilisée soit seule, soit en combinaison avec la cyclosporine A pour un effet renforcé, ces deux substances présentant des modes d'action différents. La progidiosine exerce de ce fait une action préventive et thérapeutique sur la réaction aiguë du greffon contre l'hôte.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Korean (KO)