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1. (WO2007007985) LIGAND OF REGULATING IMMUNE RESPONSE, AND USE THEREOF IN TREATING AN IMMUNE RESPONSE-RELATED DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007985 International Application No.: PCT/KR2006/002659
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
IPC:
A61K 38/08 (2006.01) ,A61K 38/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Applicants:
POSTECH FOUNDATION [KR/KR]; San 31 Hyoja-dong, Nam-ku Pohang-city Kyungsangbuk-do 790-784, KR (AllExceptUS)
POSTECH ACADEMY-INDUSTRY FOUNDATION [KR/KR]; San31 Hyoja-dong, Nam-ku Pohang-city Kyungsangbuk-do 790-784, KR (AllExceptUS)
KIM, Youn-Dong [KR/KR]; KR (UsOnly)
LEE, Byoung-Dae [KR/KR]; KR (UsOnly)
KIM, Yoe-Kyung [KR/KR]; KR (UsOnly)
BAE, Yoe-Sik [KR/KR]; KR (UsOnly)
LEE, Tae-Hoon [KR/KR]; KR (UsOnly)
SUH, Pann-Ghill [KR/KR]; KR (UsOnly)
RYU, Sung-Ho [KR/KR]; KR (UsOnly)
Inventors:
KIM, Youn-Dong; KR
LEE, Byoung-Dae; KR
KIM, Yoe-Kyung; KR
BAE, Yoe-Sik; KR
LEE, Tae-Hoon; KR
SUH, Pann-Ghill; KR
RYU, Sung-Ho; KR
Agent:
YOU ME PATENT & LAW FIRM; Seolim bldg., 649-10 Yeksam-dong, Kangnam-ku Seoul 135-080, KR
Priority Data:
60/595,45807.07.2005US
Title (EN) LIGAND OF REGULATING IMMUNE RESPONSE, AND USE THEREOF IN TREATING AN IMMUNE RESPONSE-RELATED DISEASE
(FR) LIGAND DE REGULATION DE REPONSE IMMUNITAIRE ET UTILISATION DE CELUI-CI DANS LE TRAITEMENT D'UNE MALADIE ASSOCIEE A LA REPONSE IMMUNITAIRE
Abstract:
(EN) The present invention relates to a ligand to regulate immune response, i.e., PACAP27 which is one of pituitary adenylate cyclase-activating polypeptides and Serum amyloid A (SAA), and their novel use in treating or preventing diseases associated with immune response. More specifically, the present invention relates to a complex of PACAP27-FPRL1 having a regulatory effect on immune response, and a use thereof in regulating immune response. In another aspect, the present invention relates to a complex of SAA and FPRL1, and a use thereof in inhibiting synoviocyte hyperplasia and angiogenesis and treating or preventing inflammatory diseases including Rheumatoid arthritis (RA).
(FR) La présente invention se rapporte à un ligand permettant de réguler la réponse immunitaire, autrement dit PACAP27 qui est un des polypeptides activant l'adénylate cyclase pituitaire, et l'amyloïde sérique A (SAA), ainsi que leurs nouvelles utilisations dans le traitement ou la prévention de maladies associées à la réponse immunitaire. Cette invention concerne plus spécifiquement un complexe de PACAP27-FPRL1 présentant un effet régulateur sur la réponse immunitaire et une utilisation de celui-ci dans la régulation de la réponse immunitaire. Selon un autre aspect, cette invention concerne un complexe de SAA et de FPRL1 et une utilisation de celui-ci pour inhiber l'hyperplasie des cellules synoviales et l'angiogenèse et pour traiter ou prévenir des maladies inflammatoires telles que l'arthrite rhumatoïde (RA).
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20100291089