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1. (WO2007007921) SEGMENTED GENOME TYPE RECOMBINANT MONONEGAVIRUS VECTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007921    International Application No.:    PCT/JP2006/314333
Publication Date: 18.01.2007 International Filing Date: 13.07.2006
IPC:
C12N 15/00 (2006.01), A61K 48/00 (2006.01), C12N 5/10 (2006.01)
Applicants: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP/JP]; 10-1, Hakozaki 6-chome, Higashi-ku, Fukuoka-shi, Fukuoka 8128581 (JP) (For All Designated States Except US).
DNAVEC CORPORATION [JP/JP]; 1-25-11 Kannondai, Tsukuba-shi, Ibaraki 3050856 (JP) (For All Designated States Except US).
TAKEDA, Makoto [JP/JP]; (JP) (For US Only).
YANAGI, Yusuke [JP/JP]; (JP) (For US Only).
YOU, Jun [CN/JP]; (JP) (For US Only).
INOUE, Makoto [JP/JP]; (JP) (For US Only).
HASEGAWA, Mamoru [JP/JP]; (JP) (For US Only)
Inventors: TAKEDA, Makoto; (JP).
YANAGI, Yusuke; (JP).
YOU, Jun; (JP).
INOUE, Makoto; (JP).
HASEGAWA, Mamoru; (JP)
Agent: KOBAYASHI, Hiroshi; c/o ABE, IKUBO & KATAYAMA Fukuoka Bldg. 9th Fl. 8-7, Yaesu 2-chome Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
60/699,101 13.07.2005 US
Title (EN) SEGMENTED GENOME TYPE RECOMBINANT MONONEGAVIRUS VECTOR
(FR) VECTEUR DE MONONÉGAVIRUS RECOMBINANT DE TYPE GÉNOME FRACTIONNÉ
(JA) 分節ゲノム型組換えモノネガウイルスベクター
Abstract: front page image
(EN)Disclosed is a recombinant mononegavirus vector which can express a foreign gene at a high level while retaining a good proliferation ability inherent to the virus itself, of which expression efficiency is hardly affected by the length or type of the foreign gene, and which can have multiple foreign genes inserted therein. A recombinant mononegavirus vector having a genome segmented into two or more segments, at least one of the genome segments including a foreign gene capable of being expressed in a host.
(FR)Cette invention concerne un vecteur de mononégavirus recombinant qui peut exprimer un gène étranger à un niveau élevé tout en conservant une bonne capacité de prolifération inhérente au virus lui-même, dont l’efficacité d’expression n’est pratiquement pas affectée par la longueur ou le type du gène étranger, et dans lequel plusieurs gènes étrangers peuvent être insérés. L’invention porte sur un vecteur de mononégavirus recombinant ayant un génome segmenté en deux segments ou plus, et dont au moins un de ces segments inclut un gène étranger capable d’être exprimé dans un hôte.
(JA)本発明は、ウイルス本来の良好な増殖能を保持しつつ外来遺伝子を高発現させることができ、しかも、外来遺伝子の長さ及び種類による発現効率への影響が小さく、複数個の外来遺伝子を挿入することができる組換えモノネガウイルスベクターを提供する。本発明の組換えモノネガウイルスベクターは、複数に分節されたゲノムを保持し、少なくとも1つの分節ゲノムが宿主内で発現可能な外来遺伝子を含むことを特徴とする。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)