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1. (WO2007007921) SEGMENTED GENOME TYPE RECOMBINANT MONONEGAVIRUS VECTOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007921 International Application No.: PCT/JP2006/314333
Publication Date: 18.01.2007 International Filing Date: 13.07.2006
IPC:
C12N 15/00 (2006.01) ,A61K 48/00 (2006.01) ,C12N 5/10 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants:
国立大学法人九州大学 KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP/JP]; 〒8128581 福岡県福岡市東区箱崎六丁目10番1号 Fukuoka 10-1, Hakozaki 6-chome, Higashi-ku, Fukuoka-shi, Fukuoka 8128581, JP (AllExceptUS)
ディナベック株式会社 DNAVEC CORPORATION [JP/JP]; 〒3050856 茨城県つくば市観音台1-25-11 Ibaraki 1-25-11 Kannondai, Tsukuba-shi, Ibaraki 3050856, JP (AllExceptUS)
竹田 誠 TAKEDA, Makoto [JP/JP]; JP (UsOnly)
柳 雄介 YANAGI, Yusuke [JP/JP]; JP (UsOnly)
游 軍 YOU, Jun [CN/JP]; JP (UsOnly)
井上 誠 INOUE, Makoto [JP/JP]; JP (UsOnly)
長谷川 護 HASEGAWA, Mamoru [JP/JP]; JP (UsOnly)
Inventors:
竹田 誠 TAKEDA, Makoto; JP
柳 雄介 YANAGI, Yusuke; JP
游 軍 YOU, Jun; JP
井上 誠 INOUE, Makoto; JP
長谷川 護 HASEGAWA, Mamoru; JP
Agent:
小林 浩 KOBAYASHI, Hiroshi; 〒1040028 東京都中央区八重洲二丁目8番7号 福岡ビル9階 阿部・井窪・片山法律事務所 Tokyo c/o ABE, IKUBO & KATAYAMA Fukuoka Bldg. 9th Fl. 8-7, Yaesu 2-chome Chuo-ku, Tokyo 1040028, JP
Priority Data:
60/699,10113.07.2005US
Title (EN) SEGMENTED GENOME TYPE RECOMBINANT MONONEGAVIRUS VECTOR
(FR) VECTEUR DE MONONÉGAVIRUS RECOMBINANT DE TYPE GÉNOME FRACTIONNÉ
(JA) 分節ゲノム型組換えモノネガウイルスベクター
Abstract:
(EN) Disclosed is a recombinant mononegavirus vector which can express a foreign gene at a high level while retaining a good proliferation ability inherent to the virus itself, of which expression efficiency is hardly affected by the length or type of the foreign gene, and which can have multiple foreign genes inserted therein. A recombinant mononegavirus vector having a genome segmented into two or more segments, at least one of the genome segments including a foreign gene capable of being expressed in a host.
(FR) Cette invention concerne un vecteur de mononégavirus recombinant qui peut exprimer un gène étranger à un niveau élevé tout en conservant une bonne capacité de prolifération inhérente au virus lui-même, dont l’efficacité d’expression n’est pratiquement pas affectée par la longueur ou le type du gène étranger, et dans lequel plusieurs gènes étrangers peuvent être insérés. L’invention porte sur un vecteur de mononégavirus recombinant ayant un génome segmenté en deux segments ou plus, et dont au moins un de ces segments inclut un gène étranger capable d’être exprimé dans un hôte.
(JA) 本発明は、ウイルス本来の良好な増殖能を保持しつつ外来遺伝子を高発現させることができ、しかも、外来遺伝子の長さ及び種類による発現効率への影響が小さく、複数個の外来遺伝子を挿入することができる組換えモノネガウイルスベクターを提供する。本発明の組換えモノネガウイルスベクターは、複数に分節されたゲノムを保持し、少なくとも1つの分節ゲノムが宿主内で発現可能な外来遺伝子を含むことを特徴とする。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)