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1. (WO2007007910) HETEROCYCLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007910 International Application No.: PCT/JP2006/314307
Publication Date: 18.01.2007 International Filing Date: 12.07.2006
IPC:
C07D 405/14 (2006.01) ,A61K 31/4439 (2006.01) ,A61K 31/497 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/10 (2006.01) ,A61P 43/00 (2006.01) ,C07D 409/14 (2006.01) ,C07D 413/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
Applicants:
萬有製薬株式会社 BANYU PHARMACEUTICAL CO., LTD. [JP/JP]; 〒1028667 東京都千代田区九段北一丁目13番12号 北の丸スクエア Tokyo Kitanomaru Square, 1-13-12 Kudankita, Chiyoda-ku, Tokyo 1028667, JP (AllExceptUS)
荻野 悦夫 OGINO, Yoshio [JP/JP]; JP (UsOnly)
野々下 克昌 NONOSHITA, Katsumasa [JP/JP]; JP (UsOnly)
西村 輝之 NISHIMURA, Teruyuki [JP/JP]; JP (UsOnly)
永木 淳一 EIKI, Jun-ichi [JP/JP]; JP (UsOnly)
Inventors:
荻野 悦夫 OGINO, Yoshio; JP
野々下 克昌 NONOSHITA, Katsumasa; JP
西村 輝之 NISHIMURA, Teruyuki; JP
永木 淳一 EIKI, Jun-ichi; JP
Common
Representative:
萬有製薬株式会社 BANYU PHARMACEUTICAL CO., LTD.; 〒1028667 東京都千代田区九段北一丁目13番12号 北の丸スクエア Tokyo Kitanomaru Square 1-13-12 Kudankita Chiyoda-ku Tokyo 102-8667, JP
Priority Data:
2005-20443813.07.2005JP
Title (EN) HETEROCYCLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE
(FR) DÉRIVÉ DU BENZIMIDAZOLE À SUBSTITUTION PAR UN HÉTÉROCYCLE
(JA) ヘテロ環置換ベンズイミダゾール誘導体
Abstract:
(EN) A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein X1 to X4 independently represent a carbon atom or the like; the ring A represents a 5- to 6-membered heteroaryl having 1 to 4 heteroatoms independently selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom; X5 represents an oxygen atom or the like; X represents a carbon atom or the like; Het represents a 5- or 6-membered aliphatic heterocycle; R1 represents an aryl or the like; R2 represents a formyl group or the like; and R3 represents a -C1-6 alkyl or the like. The compound or salt has a glucokinase activation effect and is useful as a therapeutic agent for diabetes.
(FR) La présente invention concerne un composé représenté par la formule (I) ou un de ses sels pharmaceutiquement acceptable : (I) dans laquelle X1 à X4 représentent indépendamment un atome de carbone ou un atome similaire ; le cycle A représente un hétéroaryle à 5 ou 6 chaînons ayant de 1 à 4 hétéroatomes indépendamment choisis dans le groupe comprenant un atome d'azote, un atome de soufre et un atome d'oxygène ; X5 représente un atome d'oxygène ou un atome similaire ; X représente un atome de carbone ou un atome similaire ; Het représente un hétérocycle aliphatique à 5 ou 6 chaînons ; R1 représente un aryle ou un groupe similaire ; R2 représente un groupe formyle ou un groupe similaire ; et R3 représente un alkyle en -C1-6 ou un groupe similaire. Le composé ou le sel a un effet d'activation de la glucokinase et il est utile en tant qu'agent thérapeutique du diabète.
(JA) 本発明は、グルコキナーゼ活性化作用を有し、糖尿病の治療剤として有用な式(I)[式中、X乃至X4は炭素原子等を示し、A環は、窒素原子、硫黄原子及び酸素原子からなる群より選択されるヘテロ原子を1乃至4有する5乃至6員のヘテロアリールを示し、Xは酸素原子等を示し、Xは炭素原子等を示し、Hetは5又は6員の脂肪族ヘテロ環を示し、Rはアリール等を示し、Rはホルミル等を示し、Rは−C1−6アルキル等を示す]で表される化合物又はその薬学的に許容される塩に関する。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP1905769JPWO2007007910US20100087360CA2614544JP5281287AU2006267338