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1. (WO2007007886) AN OXIME DERIVATIVE AND PREPARATIONS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007886    International Application No.:    PCT/JP2006/314117
Publication Date: 18.01.2007 International Filing Date: 10.07.2006
IPC:
C07D 417/12 (2006.01), C07D 417/14 (2006.01), C07D 513/04 (2006.01), C07D 213/75 (2006.01), C07D 277/46 (2006.01), C07D 285/08 (2006.01), C07D 241/20 (2006.01), C07D 403/06 (2006.01), C07D 405/12 (2006.01), C07D 405/14 (2006.01), A61K 31/433 (2006.01), A61P 3/04 (2006.01), A61P 3/10 (2006.01), A61P 9/10 (2006.01), C07C 251/32 (2006.01)
Applicants: Mitsubishi Tanabe Pharma Corporation [JP/JP]; 2-10, Dosho-machi 3-chome, Chuo-ku, Osaka-shi, Osaka, 5418505 (JP) (For All Designated States Except US).
SUGAWARA, Kazutoshi [JP/JP]; (JP) (For US Only).
MATSUDAIRA, Tetsuji [JP/JP]; (JP) (For US Only).
SUGAMA, Hiroshi [JP/JP]; (JP) (For US Only).
NAWANO, Masao [JP/JP]; (JP) (For US Only).
OHASHI, Rikiya [JP/JP]; (JP) (For US Only)
Inventors: SUGAWARA, Kazutoshi; (JP).
MATSUDAIRA, Tetsuji; (JP).
SUGAMA, Hiroshi; (JP).
NAWANO, Masao; (JP).
OHASHI, Rikiya; (JP)
Agent: KAWAMIYA, Osamu; AOYAMA & PARTNERS, IMP Building, 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi, Osaka 5400001 (JP)
Priority Data:
2005-202014 11.07.2005 JP
2006-114243 18.04.2006 JP
Title (EN) AN OXIME DERIVATIVE AND PREPARATIONS THEREOF
(FR) DERIVE D'OXIME ET SES PREPARATIONS
Abstract: front page image
(EN)The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R3 and R4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.
(FR)L'invention concerne un composé utilisé comme agent d'activation de la glucokinase, qui est un dérivé d'oxime représenté par la formule [I]. Dans cette formule, le noyau A représente aryle ou hétéroaryle; Q représente cycloalkyle, hétérocycle, alkyle ou alcényle; le noyau T représente hétéroaryle ou hétérocycle; R1 et R2 représentent indépendamment un atome d'hydrogène, un atome d'halogène, cycloalkylsulfonyle ou analogue; R3 et R4 représentent indépendamment un atome d'hydrogène, hydroxy, oxo, un atome d'halogène ou analogue; R5 représente un atome d'hydrogène, un atome d'halogène, cyano, nitro, tétrazolyle ou analogue. L'invention concerne également un sel de ce composé pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)