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1. (WO2007007832) PRESERVATIVE COMPOSITION FOR OPHTHALMIC USE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007832 International Application No.: PCT/JP2006/313944
Publication Date: 18.01.2007 International Filing Date: 13.07.2006
IPC:
A61K 47/04 (2006.01) ,A61K 47/10 (2006.01) ,A61K 47/22 (2006.01) ,A61K 47/26 (2006.01) ,A61K 47/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
04
Non-metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
22
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
Applicants:
参天製薬株式会社 SANTEN PHARMACEUTICAL CO., LTD. [JP/JP]; 〒5338651 大阪府大阪市東淀川区下新庄3丁目9番19号 Osaka 9-19, Shimoshinjo 3-chome, Higashiyodogawa-ku, Osaka-shi, Osaka 5338651, JP (AllExceptUS)
高田 浩一 TAKADA, Koichi [JP/JP]; JP (UsOnly)
木村 章男 KIMURA, Akio [JP/JP]; JP (UsOnly)
桶本 美紀子 OKEMOTO, Mikiko [JP/JP]; JP (UsOnly)
Inventors:
高田 浩一 TAKADA, Koichi; JP
木村 章男 KIMURA, Akio; JP
桶本 美紀子 OKEMOTO, Mikiko; JP
Agent:
日比 紀彦 HIBI, Norihiko; 〒5420086 大阪府大阪市中央区西心斎橋1丁目13番18号 イナバビル3階 キシモト特許事務所内 Osaka c/o KISHIMOTO & CO. 3rd Floor, Inaba Building 13-18, Nishishinsaibashi 1-chome Chuo-ku, Osaka-shi Osaka 5420086, JP
Priority Data:
2005-20447213.07.2005JP
Title (EN) PRESERVATIVE COMPOSITION FOR OPHTHALMIC USE
(FR) COMPOSITION CONSERVATRICE À USAGE OPHTALMIQUE
(JA) 眼科用防腐組成物
Abstract:
(EN) The object is to prevent the generation of chlorine dioxide in a liquid preparation for ophthalmic use containing a hypochlorite. A liquid preparation for ophthalmic use comprising a preservative composition for ophthalmic use which comprises a hypochlorite and at least one stabilizer selected from the following substances 1) to 7): 1) creatinine; 2) geraniol; 3) glucose; 4) tocopherol acetate; 5) oxiquinoline sulfate; 6) a sugar alcohol; and 7) a polyoxyethylene sorbitan fatty acid ester. The liquid preparation can prevent the generation of chlorine dioxide, and is therefore excellent in safety and shows a sustained preservative effect for a prolonged period of time.
(FR) La présente invention a pour objet de prévenir la génération de dioxyde de chlore dans une préparation liquide à usage ophtalmique contenant un hypochlorite. Elle concerne une préparation liquide à usage ophtalmique comprenant une composition conservatrice à usage ophtalmique qui comprend un hypochlorite et au moins un agent stabilisant sélectionné parmi les substances suivantes 1) à 7) : 1) créatinine ; 2) géraniol ; 3) glucose ; 4) acétate de tocophérol ; 5) sulfate d’oxiquinoline ; 6) un alcool de sucre ; et 7) un ester d'acide gras de sorbitan de polyoxyéthylène. La préparation liquide peut prévenir la génération de dioxyde de chlore et présente en conséquence une excellente innocuité et montre un effet conservateur soutenu pendant une période de temps prolongée.
(JA)  本発明は、亜塩素酸塩を含有する眼科用液剤について、二酸化塩素の発生を抑制することを課題とする。亜塩素酸塩と下記1)~7)から選択される少なくとも一つの安定化剤とからなる眼科用防腐組成物を含有する眼科用液剤は、二酸化塩素の発生を抑制するので安全性に優れ、長期に渡って防腐効果が持続する。1)クレアチニン、2)ゲラニオール、3)グルコース、4)酢酸トコフェロール、5)硫酸オキシキノリン、6)糖アルコール、7)ポリオキシエチレンソルビタン脂肪酸エステル
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
NO20080725KR1020080039342EP1905453JP2007045819US20080269353RU0002413534
ES2393675CN101222939CA2615108PT1905453DK1905453