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1. (WO2007007668) THERAPEUTIC AGENT AND TREATMENT METHOD FOR AMELIORATING UREMIA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007668 International Application No.: PCT/JP2006/313572
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
IPC:
A61K 31/5578 (2006.01) ,A61K 31/5585 (2006.01) ,A61P 13/12 (2006.01) ,C07D 307/93 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
557
Eicosanoids, e.g. leukotrienes
5578
having a pentalene ring system, e.g. carbacyclin, iloprost
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
557
Eicosanoids, e.g. leukotrienes
558
having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
5585
having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
93
condensed with a ring other than six-membered
Applicants:
東レ株式会社 Toray Industries, Inc. [JP/JP]; 〒1038666 東京都中央区日本橋室町2丁目1番1号 Tokyo 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666, JP (AllExceptUS)
竹中 雅彦 TAKENAKA, Masahiko [JP/JP]; JP (UsOnly)
山根 義久 YAMANE, Yoshihisa [JP/JP]; JP (UsOnly)
井田 亘隆 IDA, Nobutaka [JP/JP]; JP (UsOnly)
車谷 元 KURUMATANI, Hajimu [JP/JP]; JP (UsOnly)
Inventors:
竹中 雅彦 TAKENAKA, Masahiko; JP
山根 義久 YAMANE, Yoshihisa; JP
井田 亘隆 IDA, Nobutaka; JP
車谷 元 KURUMATANI, Hajimu; JP
Agent:
谷川 英次郎 TANIGAWA, Hidejiro; 〒1020072 東京都千代田区飯田橋4丁目5番12号岩田ビル6階 谷川国際特許事務所内 Tokyo c/o TANIGAWA AND ASSOCIATES, Patent Firm 6F, Iwata Bldg. 5-12, Iidabashi 4-chome Chiyoda-ku, Tokyo 1020072, JP
Priority Data:
2005-20088808.07.2005JP
Title (EN) THERAPEUTIC AGENT AND TREATMENT METHOD FOR AMELIORATING UREMIA
(FR) AGENT THÉRAPEUTIQUE ET PROCÉDÉ DE TRAITEMENT SERVANT À AMÉLIORER L'URÉMIE
(JA) 尿毒症改善のための治療剤および処置方法
Abstract:
(EN) A therapeutic agent for uremia in humans and animals, which can be easily taken, has fewer adverse effects and is economically inexpensive in a medical treatment and a method of treating uremia are disclosed. A therapeutic agent for uremia in chronic renal failure patients contains a prostaglandin I2 derivative with a specific structure such as beraprost sodium as an active ingredient. The therapeutic agent for uremia ameliorates an intercurrent uremia in a chronic renal failure patient without causing adverse effects and recovery of decreased appetite, improvement in activity, increase in body weight and the like are achieved. The therapeutic effect on uremia is clear reduction or disappearance of uremic symptoms which is observed despite renal failure conditions, particularly the progression of decrease in renal function and can be recognized as a clinical condition.
(FR) Il est exposé un agent thérapeutique pour l'urémie chez des êtres humains et des animaux, lequel peut être pris facilement, a moins d'effets négatifs et est bon marché lors d'un traitement médical et un procédé de traitement de l'urémie. Un agent thérapeutique pour l'urémie chez des patients souffrant d'insuffisance rénale chronique contient un dérivé de la prostaglandine I2 ayant une structure spécifique tel que le beraprost sodium comme ingrédient actif. L'agent thérapeutique pour l'urémie améliore une urémie intercurrente chez un patient souffrant d'insuffisance rénale chronique sans provoquer d'effets négatifs et on parvient à réaliser la récupération d'un appétit diminué, l'amélioration de l'activité, l'augmentation du poids corporel et similaire. L'effet thérapeutique sur l'urémie est la réduction visible ou la disparition des symptômes urémiques qui est observée malgré les affections d'insuffisance rénale, en particulier la progression de la diminution de la fonction rénale, et peut être reconnu cliniquement.
(JA) 簡単に服用でき、副作用が少なく、医療経済上も高額とならないヒトおよび動物の尿毒症治療剤および処置方法が開示されている。慢性腎不全患者における尿毒症治療剤は、ベラプロストナトリウムのような、特定の構造を有するプロスタグランジンI2誘導体を有効成分として含有する。尿毒症治療剤は、慢性腎不全患者に併発した尿毒症を、副作用を伴うことなく改善させ、低下した食欲の回復、活動性の改善、体重の増加等が達成される。尿毒症の治療効果は、腎不全状態、特に腎機能の低下が進行しているにもかかわらず認められる、臨床症状として把握できる明確な尿毒症状の軽減ないしは消失である。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020080024203EP1913946JPWO2007007668US20090143463CN101217960CA2618708
ES2451627PT1913946AU2006267613US20170224652