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1. (WO2007007665) THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007665    International Application No.:    PCT/JP2006/313564
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
IPC:
A61K 39/395 (2006.01), A61P 9/10 (2006.01)
Applicants: SAITAMA MEDICAL SCHOOL [JP/JP]; 38, Morohongoh, Moroyama-machi, Iruma-gun, Saitama 3500495 (JP) (For All Designated States Except US).
SUDA, Tatsuo [JP/JP]; (JP) (For US Only).
KATAGIRI, Takenobu [JP/JP]; (JP) (For US Only).
KODAIRA, Kunihiko [JP/JP]; (JP) (For US Only).
GOTO, Masaaki [JP/JP]; (JP) (For US Only).
HIGASHIO, Kanji [JP/JP]; (JP) (For US Only)
Inventors: SUDA, Tatsuo; (JP).
KATAGIRI, Takenobu; (JP).
KODAIRA, Kunihiko; (JP).
GOTO, Masaaki; (JP).
HIGASHIO, Kanji; (JP)
Agent: SHAMOTO, Ichio; YUASA AND HARA Section 206, New Ohtemachi Bldg. 2-1, Ohtemachi 2-chome Chiyoda-ku, Tokyo 1000004 (JP)
Priority Data:
2005-198977 07.07.2005 JP
Title (EN) THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS
(FR) AGENT THERAPEUTIQUE CONTRE L'ARTERIOSCLEROSE
(JA) 動脈硬化の治療剤
Abstract: front page image
(EN)A prophylactic and/or therapeutic agent for arteriosclerosis comprising an antibody directed against platelet factor 4 (PF4) (an anti-PF4 antibody) as an active ingredient; an inhibitor of the calcification in the blood vessel and/or the calcification in an atherosclerotic plaque comprising an anti-PF4 antibody as an active ingredient; an inhibitor of the differentiation of an arterial smooth muscle cell into an osteoblast-like cell comprising an anti-PF4 antibody as an active ingredient; and a method for inhibiting the differentiation of an arterial smooth muscle cell into an osteoblast-like cell using an anti-PF4 antibody.
(FR)L'invention concerne un agent prophylactique et/ou thérapeutique contre l'artériosclérose, qui comprend un anticorps dirigé contre le facteur plaquettaire 4 (PF4) (un anticorps anti-PF4) comme ingrédient actif; un inhibiteur de la calcification dans le vaisseau sanguin et/ou de la calcification dans une plaque d'athérosclérose comprenant un anticorps anti-PF4 comme ingrédient actif; un inhibiteur de différenciation d'une cellule du muscle lisse artériel en une cellule de type ostéoblaste comprenant un anticorps anti-PF4 comme ingrédient actif. L'invention concerne en outre une méthode pouvant inhiber la différenciation d'une cellule du muscle lisse artériel en une cellule de type ostéoblaste utilisant un anticorps anti-PF4.
(JA) 血小板第4因子(PF4)に対する抗体(抗PF4抗体)を有効成分として含有する動脈硬化の予防および/または治療剤、抗PF4抗体を有効成分として含有する血管石灰化および/またはアテローム性動脈硬化プラークの石灰化抑制剤、抗PF4抗体を有効成分として含有する動脈平滑筋細胞から骨芽細胞様細胞への分化抑制剤、及び抗PF4抗体を用いる動脈平滑筋細胞から骨芽細胞様細胞への分化を抑制する方法。                                                                                 
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)