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1. (WO2007007588) COMPOUND HAVING CYCLIC GROUP WITH PLANARITY AS CORE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007588    International Application No.:    PCT/JP2006/313290
Publication Date: 18.01.2007 International Filing Date: 04.07.2006
IPC:
C07D 409/14 (2006.01), A61K 31/4245 (2006.01), A61K 31/454 (2006.01), A61K 31/5377 (2006.01), A61K 31/551 (2006.01), A61P 3/04 (2006.01), A61P 3/06 (2006.01), A61P 3/10 (2006.01), A61P 7/02 (2006.01), A61P 9/00 (2006.01), A61P 9/08 (2006.01), A61P 9/12 (2006.01), A61P 25/28 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), C07D 413/10 (2006.01), C07D 413/14 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418526 (JP) (For All Designated States Except US).
TORISU, Kazuhiko [JP/JP]; (JP) (For US Only).
SAKAI, Masaru [JP/JP]; (JP) (For US Only)
Inventors: TORISU, Kazuhiko; (JP).
SAKAI, Masaru; (JP)
Agent: IWATANI, Ryo; ORIX Dojima Bldg. 3F 1-31, Dojima 2-chome Kita-ku, Osaka-shi Osaka 530-0003 (JP)
Priority Data:
2005-200329 08.07.2005 JP
Title (EN) COMPOUND HAVING CYCLIC GROUP WITH PLANARITY AS CORE
(FR) COMPOSE COMPORTANT UN GROUPE CYCLIQUE AYANT UN NOYAU PLAN
(JA) 平面性を有する環状基を母核とする化合物
Abstract: front page image
(EN)Disclosed is a compound having aN FXa inhibitory effect, which is useful in the prevention and/or treatment of a thrombotic disease having an activated blood coagulation mechanism, such as a thrombosis/embolism associated with a cardiovascular disease, a thrombosis/embolism associated with a cerebrovascular disease and a thrombosis/embolism associated with a venous disease. A compound represented by the general formula (I), a salt or solvate of the compound or a prodrug of the compound, salt or solvate: (I) wherein the ring A represents a cyclic group having a planarity which may be substituted by a substituent; B represents a cyclic group which may be substituted by a substituent; R1 represents a substituent; and X represents a spacer for the main chain which has 1 to 5 atoms and may be further substituted by a substituent.
(FR)L'invention concerne un composé ayant un effet anti-Fxa, utile pour prévenir et/ou traiter les maladies thrombotiques ayant un mécanisme de coagulation du sang activée, telle qu'une thrombose/embolie associée avec une maladie cardiovasculaire, une thrombose/embolie associée avec une maladie cérébrovasculaire et une thrombose/embolie associée avec une maladie veineuse. L'invention concerne donc un composé représenté par la formule générale (I), un sel ou un solvate de ce composé, ou un promédicament de ce composé, sel ou solvate : (I) où le cycle A représente un groupe cyclique dont le plan peut être substitué ; B représente un groupe cyclique pouvant être substitué ; R1 représente un substituant ; et X représente un espaceur pour la chaîne principale ayant de 1 à 5 atomes et pouvant également être substitué.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)