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1. (WO2007007524) INHIBITOR OF ENZYMATIC ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007524    International Application No.:    PCT/JP2006/312490
Publication Date: 18.01.2007 International Filing Date: 22.06.2006
IPC:
A61K 31/353 (2006.01), A61K 36/18 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01), C12N 9/99 (2006.01)
Applicants: Mitsui Norin Co., Ltd. [JP/JP]; 2-9, Nishishinbashi 1-Chome, Minato-ku, Tokyo 1058427 (JP) (For All Designated States Except US).
MATSUNAGA, Jun [JP/JP]; (JP) (For US Only).
AIBA, Setsuya [JP/JP]; (JP) (For US Only).
HARA, Yukihiko [JP/JP]; (JP) (For US Only)
Inventors: MATSUNAGA, Jun; (JP).
AIBA, Setsuya; (JP).
HARA, Yukihiko; (JP)
Agent: YANO, Hiroya; E-1 Bldg., 3-12, Nihombashi 3-chome, Chuo-ku, Tokyo 1030027 (JP)
Priority Data:
2005-205085 14.07.2005 JP
Title (EN) INHIBITOR OF ENZYMATIC ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR
(FR) INHIBITEUR DE L'ACTIVITÉ ENZYMATIQUE DU FACTEUR D'INHIBITION DE LA MIGRATION DES MACROPHAGES
(JA) マクロファージ遊走阻止因子の酵素活性阻害剤
Abstract: front page image
(EN)Disclosed is a novel, highly safe inhibitor of the enzymatic activity of macrophage migration inhibitory factor (MIF). An inhibitor of the enzymatic activity of macrophage migration inhibitory factor comprising a tea catechin as an active ingredient; and an inhibitor of the inflammation induced by macrophage migration inhibitory factor and an inhibitor of the cancer cell growth induced by macrophage migration inhibitory factor both which comprise the inhibitor mentioned above.
(FR)Il est exposé un nouvel inhibiteur tout à fait sans danger de l'activité enzymatique du facteur d'inhibition de la migration des macrophages (MIF). L'invention concerne un inhibiteur de l'activité enzymatique du facteur d'inhibition de la migration des macrophages comprenant une catéchine du thé comme ingrédient actif ; et un inhibiteur de l'inflammation induite par le facteur d'inhibition de la migration des macrophages et un inhibiteur du développement de cellules cancéreuses induit par le facteur d'inhibition de la migration des macrophages lesquels comprennent tous deux l'inhibiteur mentionné ci-dessus.
(JA) 本発明の目的は、安全性の高い新規なマクロファージ遊走阻止因子(MIF)の酵素活性阻害剤を提供することである。  本発明は、茶カテキン類を有効成分とするマクロファージ遊走阻止因子の酵素活性阻害剤を提供し、さらに該阻害剤を含有するマクロファージ遊走阻止因子誘発炎症抑制剤並びにマクロファージ遊走阻止因子誘発ガン細胞増殖抑制剤を提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)