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1. (WO2007007399) THIAZOLE COMPOUND
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007399 International Application No.: PCT/JP2005/012894
Publication Date: 18.01.2007 International Filing Date: 13.07.2005
IPC:
C07D 515/22 (2006.01) ,A61K 31/437 (2006.01) ,A61P 31/04 (2006.01) ,C12P 17/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
515
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/241
22
in which the condensed system contains four or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17
Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
18
containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Applicants:
大正製薬株式会社 TAISHO PHARMACEUTICAL CO., LTD. [JP/JP]; 〒1708633 東京都豊島区高田3丁目24番1号 Tokyo 24-1, Takada 3-chome, Toshima-ku, Tokyo 1708633, JP (AllExceptUS)
SICHUAN INDUSTRIAL INSTITUTE OF ANTIBIOTICS OF CHINA NATIONAL PHARMACEUTICAL GROUP CORPORATION [CN/CN]; 18 Shanbanqiao Rd., Chenghua Dist Chengdu Sichuan 610051, CN (AllExceptUS)
野澤 由利子 NOZAWA, Yuriko [JP/JP]; JP (UsOnly)
▲チュー▼ 以文 CHU, Yi-wen [CN/CN]; CN (UsOnly)
李 俊英 LI, Jun-ying [CN/CN]; CN (UsOnly)
Inventors:
野澤 由利子 NOZAWA, Yuriko; JP
▲チュー▼ 以文 CHU, Yi-wen; CN
李 俊英 LI, Jun-ying; CN
Agent:
佐鳥 宗一 SATORI, Soichi; 〒1708633 東京都豊島区高田3丁目24番1号 大正製薬株式会社 知的財産部内 Tokyo c/o TAISHO PHARMACEUTICAL CO., LTD. INTELLECTUAL PROPERTY DIVISION 24-1, Takada 3-chome Toshima-ku, Tokyo 1708633, JP
Priority Data:
Title (EN) THIAZOLE COMPOUND
(FR) DÉRIVÉ DE THIAZOLE
(JA) チアゾール系化合物
Abstract:
(EN) Compounds having an anti-MRSA activity and having a skeleton and action mechanism different from those of existing drugs, which are useful as a novel antimicrobial agent. Conventionally, vancomycin is used as a drug for MRSA. However, recently, as, for example, vancomycin-resistant enterococcus (VRE) is reported and resistant bacteria occur, there is a demand for other drugs. Thiazole compounds of the formula: [in the formula, R is the group of the formula: or an amino] have an anti-MRSA activity and an anti-VRE activity, being useful as drugs.
(FR) La présente invention concerne des composés présentant une activité anti-MRSA et dont le squelette et le mécanisme d'action sont différents de ceux des médicaments existants, lesdits composés pouvant être employés en tant que nouveaux agents antimicrobiens. La vancomycine est couramment employée en tant que médicament contre les MRSA. Cependant, il existe depuis peu un besoin de trouver d'autres médicaments, dans la mesure où des entérocoques résistant à la vancomycine (VRE) et des souches bactériennes résistantes apparaissent. La présente invention décrit des dérivés de thiazole de formule : [dans la formule, R est le groupement de formule : ou un groupement amino] qui présentent une activité anti-MRSA et anti-VRE, et peuvent être employés en tant que médicaments.
(JA) not available
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
CN101400684