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1. (WO2007007327) IL-32 MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007327    International Application No.:    PCT/IL2006/000798
Publication Date: 18.01.2007 International Filing Date: 10.07.2006
G01N 33/68 (2006.01), A61K 38/00 (2006.01), C07K 14/00 (2006.01), A61K 31/00 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD [IL/IL]; Weizmann Institute of Science, P.O.box 95, 76100 Rehovot (IL) (For All Designated States Except US).
THE REGENTS OF THE UNIVERSITY OF COLORADO [US/US]; University of Colorado, Health Sciences Center, Division Of Infectious Diseases, B168, 4200 East Ninth Avenue, Denver, Colorado 80262 (US) (For All Designated States Except US).
NOVICK, Daniela Dr. [IL/IL]; (IL) (For US Only).
RUBINSTEIN, Menachem [IL/IL]; (IL) (For US Only).
DINARELLO, Charles, A. [US/US]; (US) (For US Only).
KIM, Soo-Hyun [KR/US]; (US) (For US Only)
Inventors: NOVICK, Daniela Dr.; (IL).
RUBINSTEIN, Menachem; (IL).
DINARELLO, Charles, A.; (US).
KIM, Soo-Hyun; (US)
Agent: EINAV, Henry; Inter-Lab Ltd., Science Based Industrial Park, Kiryat Weizmann, 76110 Nes Ziona (IL)
Priority Data:
169622 11.07.2005 IL
Abstract: front page image
(EN)The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by- inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).
(FR)L'invention concerne des procédés de criblage de modulateurs de l'interleukine 32 (IL-32), des modulateurs de l'IL-32 et l'utilisation de ceux-ci.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)