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1. (WO2007007192) USE OF IONIC MATRICES FOR MALDI MASS SPECTROMETRY ANALYSIS OF TISSUE SECTIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007192 International Application No.: PCT/IB2006/002311
Publication Date: 18.01.2007 International Filing Date: 07.06.2006
IPC:
G01N 27/64 (2006.01) ,G01N 30/72 (2006.01) ,G01N 33/483 (2006.01) ,H01J 49/16 (2006.01) ,G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
62
by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
64
using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30
Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02
Column chromatography
62
Detectors specially adapted therefor
72
Mass spectrometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
H ELECTRICITY
01
BASIC ELECTRIC ELEMENTS
J
ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49
Particle spectrometers or separator tubes
02
Details
10
Ion sources; Ion guns
16
using surface ionisation, e.g. field-, thermionic- or photo-emission
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR/FR]; 3, rue Michel-Ange F-75016 Paris, FR (AllExceptUS)
UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE [FR/FR]; F-59650 Villeneuve D'Ascq, FR (AllExceptUS)
LEMAIRE, Rémi [FR/FR]; FR (UsOnly)
FOURNIER, Isabelle [FR/FR]; FR (UsOnly)
SALZET, Michel [FR/FR]; FR (UsOnly)
TABET, Edmond, Jean-Claude [FR/FR]; FR (UsOnly)
Inventors:
LEMAIRE, Rémi; FR
FOURNIER, Isabelle; FR
SALZET, Michel; FR
TABET, Edmond, Jean-Claude; FR
Agent:
SCHRIMPF, Robert; Cabinet Regimbeau 20, rue de Chazelles F-75847 Paris Cedex 17, FR
Priority Data:
60/687,84807.06.2005US
Title (EN) USE OF IONIC MATRICES FOR MALDI MASS SPECTROMETRY ANALYSIS OF TISSUE SECTIONS
(FR) UTILISATION DE MATRICES IONIQUES POUR L'ANALYSE PAR LA SPECTROMETRIE DE DESORPTION-IONISATION PAR IMPACT LASER ASSISTEE PAR MATRICE
Abstract:
(EN) The invention concerns improved methods for studying peptides/proteins expression in a tissue section or for determining at least one compound, in particular a protein, expression map in a tissue section, using ionic MALDI matrices.
(FR) La présente invention a trait à des procédés améliorés pour l'étude de l'expression de peptides/protéines dans une section de tissu ou pour la détermination d'au moins une carte d'expression de composé, notamment une protéine, dans une section de tissu, au moyen de matrices ioniques de désorption-ionisation par impact laser assistée par matrice.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1891426EP2287602JP2008542784US20080203289CA2611297