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1. (WO2007007132) ARIPIPRAZOLE SALTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007132 International Application No.: PCT/HU2006/000056
Publication Date: 18.01.2007 International Filing Date: 11.07.2006
Chapter 2 Demand Filed: 13.02.2007
IPC:
C07D 215/22 (2006.01) ,A61K 31/4704 (2006.01) ,A61P 25/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Oxygen atoms
22
attached in position 2 or 4
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4704
2-Quinolinones, e.g. carbostyril
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
18
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants:
EGIS GYOGYSZERGYAR Nyilvánosan Működő Részvénytársaság [HU/HU]; Keresztúri út 30-38 H-1106 Budapest, HU (AllExceptUS)
PONGÓ, László [HU/HU]; HU (UsOnly)
SIMIG, Gyula [HU/HU]; HU (UsOnly)
DANCSÓ, András [HU/HU]; HU (UsOnly)
MOROVJÁN, György [HU/HU]; HU (UsOnly)
Inventors:
PONGÓ, László; HU
SIMIG, Gyula; HU
DANCSÓ, András; HU
MOROVJÁN, György; HU
Agent:
ADVOPATENT; Office of Patent and Trademark Attorneys P.O. Box 80 H-1255 Budapest, HU
Priority Data:
P050068314.07.2005HU
Title (EN) ARIPIPRAZOLE SALTS
(FR) SELS D'ARIPIPRAZOLE
Abstract:
(EN) The present invention provides for new salts of aripiprazole of the general formula (II) formed with dibasic organic acids, camphorsulfonic acid, phosphoric acid, and processes for their preparation. Further objects of the present invention are pharmaceutical compositions containing said new aripiprazole salts. Aripiprazole salts according to present invention can be prepared by the reaction of aripiprazole base and suitable acid compounds in a molar ratio 0.5-3 based on the molar amount of aripiprazole in a suitable organic solvent.
(FR) La présente invention concerne de nouveaux sels d'aripiprazole de formule générale (II) constitués d'acides organiques dibasiques, d'acide camphorsulfonique, d'acide phosphorique; et des méthodes de préparation desdits sels. L'invention concerne également des compositions pharmaceutiques contenant lesdits nouveaux sels d'aripiprazole. Les sels d'aripiprazole de l'invention peuvent être préparés par réaction d'une base d'aripiprazole et de composés acides appropriés, selon un rapport molaire de 0,5-3, sur la base de la concentration molaire d'aripiprazole présente dans un solvant organique approprié.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080788SK50152008EP1907364JP2009501204RU02384572US20090111829
CN101238105EA200800304IN181/DELNP/2008