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1. (WO2007007119) PROCESSES FOR THE MANUFACTURE OF ROSUVASTATIN AND INTERMEDIATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007119 International Application No.: PCT/GB2006/003543
Publication Date: 18.01.2007 International Filing Date: 03.07.2006
IPC:
C07D 239/42 (2006.01) ,C07D 239/36 (2006.01) ,C07D 239/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
42
One nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32
One oxygen, sulfur or nitrogen atom
34
One oxygen atom
36
as doubly bound oxygen atom or as unsubstituted hydroxy radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
30
Halogen atoms or nitro radicals
Applicants:
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate London Greater London W1K 1LN, GB (AllExceptUS)
BUTTERS, Michael [GB/GB]; GB (UsOnly)
COX, David, Kenneth [GB/GB]; GB (UsOnly)
CRABB, Jeffrey, Norman [GB/GB]; GB (UsOnly)
LENGER, Steven, Robert [US/GB]; GB (UsOnly)
MURRAY, Paul, Michael [IE/GB]; GB (UsOnly)
SNAPE, Evan, William [GB/GB]; GB (UsOnly)
Inventors:
BUTTERS, Michael; GB
COX, David, Kenneth; GB
CRABB, Jeffrey, Norman; GB
LENGER, Steven, Robert; GB
MURRAY, Paul, Michael; GB
SNAPE, Evan, William; GB
Agent:
GLOBAL INTELLECTUAL PROPERTY; AstraZeneca AB S-151 85 Södertälje, SE
Priority Data:
0514078.508.07.2005GB
Title (EN) PROCESSES FOR THE MANUFACTURE OF ROSUVASTATIN AND INTERMEDIATES
(FR) PROCEDE DE FABRICATION DE ROSUVASTATINE ET D'INTERMEDIAIRES
Abstract:
(EN) A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described. Novel intermediates and processes to make them are also described.
(FR) L'invention concerne un procédé de préparation d'un composé de formule (V), utile pour la production de rosuvastatine, par l'intermédiaire d'une réaction aldolique stéréosélective. L'invention concerne également des nouveaux intermédiaires et des procédés de production de ceux-ci.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20076660MXMX/a/2008/000362KR1020080024538IL188201AR054818EP1904456
BRPI0612851ZA2007/11085JP2009500388US20100228028CN101218210CA2614281
NZ564609AU2006268024MYPI 20063238IN55/DELNP/2008