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1. (WO2007007054) PHTHALAMIDES, SUCCINIMIDES AND RELATED COMPOUNDS AND THEIR USE AS PHARMACEUTICALS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/007054 International Application No.: PCT/GB2006/002517
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
IPC:
C07D 401/06 (2006.01) ,C07D 403/06 (2006.01) ,C07D 413/04 (2006.01) ,C07D 403/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 209/48 (2006.01) ,A61K 31/404 (2006.01) ,A61K 31/41 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
44
Iso-indoles; Hydrogenated iso-indoles
48
with oxygen atoms in positions 1 and 3, e.g. phthalimide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Sardinia House Sardinia Street London Greater London WC2A 3NL, GB (AllExceptUS)
HAMLYN, Richard John [GB/GB]; GB (UsOnly)
RIGOREAU, Laurent Jean Martin [FR/GB]; GB (UsOnly)
RAYNHAM, Tony Michael [GB/GB]; GB (UsOnly)
PRIESTLEY, Rachael Elizabeth [GB/GB]; GB (UsOnly)
SOUDY, Christelle Nicole Marguerite [FR/GB]; GB (UsOnly)
LYKO, Frank [DE/DE]; DE (UsOnly)
BRUCKNER, Bodo [DE/DE]; DE (UsOnly)
KERN, Oliver Thomas [GB/GB]; GB (UsOnly)
Inventors:
HAMLYN, Richard John; GB
RIGOREAU, Laurent Jean Martin; GB
RAYNHAM, Tony Michael; GB
PRIESTLEY, Rachael Elizabeth; GB
SOUDY, Christelle Nicole Marguerite; GB
LYKO, Frank; DE
BRUCKNER, Bodo; DE
KERN, Oliver Thomas; GB
Agent:
WATSON, Robert ; Mewburn Ellis LLP York House 23 Kingsway London Greater London WC2B 6HP, GB
Priority Data:
0514041.308.07.2005GB
60/698,17611.07.2005US
Title (EN) PHTHALAMIDES, SUCCINIMIDES AND RELATED COMPOUNDS AND THEIR USE AS PHARMACEUTICALS
(FR) PHTHALAMIDES, SUCCINIMIDES, COMPOSES APPARENTES ET LEUR UTILISATION EN TANT QUE PRODUITS PHARMACEUTIQUES
Abstract:
(EN) The present invention relates to certain phthalamides, succinimides and related compounds and their use as pharmaceuticals. In particular, the present invention relates to these compounds, pharmaceutical compositions comprising these compounds, and use of these compounds, for example, to inhibit DNA methylation in cells, particularly tumour cells.
(FR) L'invention concerne certains phthalamides, succinimides et composés apparentés et leur utilisation en tant que produits pharmaceutiques. L'invention porte notamment sur ces composés, sur des compositions pharmaceutiques comprenant ces composés et sur l'utilisation de ces composés, par exemple pour inhiber la méthylation de l'ADN dans des cellules, notamment des cellules tumorales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)