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1. (WO2007007041) HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007041    International Application No.:    PCT/GB2006/002471
Publication Date: 18.01.2007 International Filing Date: 03.07.2006
IPC:
C07D 417/14 (2006.01), C07D 401/14 (2006.01), C07D 403/14 (2006.01), C07D 413/14 (2006.01), C07D 405/14 (2006.01), A61K 31/44 (2006.01), A61P 3/04 (2006.01), A61P 3/06 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-SE-151 85 Södertälje (SE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ASTRAZENECA UK LIMITED [GB/GB]; 15 Stanhope Gate, London, Greater London W1K 1LN (GB) (MG only).
MCKERRECHER, Darren [GB/GB]; (GB) (For US Only).
PIKE, Kurt, Gordon [GB/GB]; (GB) (For US Only).
WARING, Michael, James [GB/GB]; (GB) (For US Only)
Inventors: MCKERRECHER, Darren; (GB).
PIKE, Kurt, Gordon; (GB).
WARING, Michael, James; (GB)
Agent: GLOBAL INTELLECTUAL PROPERTY; Astrazeneca Ab, S-SE-151 85 Södertälje (SE)
Priority Data:
0514173.4 09.07.2005 GB
0516297.9 09.08.2005 GB
0523862.1 24.11.2005 GB
0524589.9 02.12.2005 GB
0607977.6 22.04.2006 GB
Title (EN) HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES
(FR) DÉRIVÉS D’HÉTÉROARYL BENZAMIDE UTILISÉS EN TANT QU’ACTIVATEURS DE LA GLK DANS LE TRAITEMENT DU DIABÈTE
Abstract: front page image
(EN)Compounds of formula (I) wherein R1, HET-1 and HET-2 are as described in the specification, and their salts and pro-drugs, are activators of glucokinase (GLK) and are thereby useful in the treatment of, for example, type 2 diabetes. Processes for preparing compounds of formula (I) are also described.
(FR)La présente invention concerne des composés de formule (I), R1, HET-1 et HET-2 étant tels que définis dans la description, ainsi que leurs sels et promédicaments, qui sont des activateurs de la glucokinase (GLK) et sont par conséquent utiles dans le traitement du diabète de type 2, par exemple. L’invention concerne également des procédés de préparation des composés de formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)