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Machine translation
1. (WO2007007018) PIPERAZINE HETEROARYL DERIVATES AS GPR38 AGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/007018    International Application No.:    PCT/GB2005/002731
Publication Date: 18.01.2007 International Filing Date: 12.07.2005
IPC:
C07D 205/04 (2006.01), C07D 205/06 (2006.01), C07D 207/12 (2006.01), C07D 207/14 (2006.01), C07D 213/40 (2006.01), C07D 213/48 (2006.01), C07D 213/55 (2006.01), C07D 213/61 (2006.01), C07D 213/65 (2006.01), C07D 213/68 (2006.01), C07D 213/71 (2006.01), C07D 213/74 (2006.01), C07D 233/60 (2006.01), C07D 277/30 (2006.01), C07D 277/28 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN (GB) (For All Designated States Except US).
MACDONALD, Gregor, James [GB/GB]; (GB) (For US Only).
STANWAY, Steven, James [GB/GB]; (GB) (For US Only).
THOMPSON, Mervyn [GB/GB]; (GB) (For US Only).
WESTAWAY, Susan, Marie [GB/GB]; (GB) (For US Only)
Inventors: MACDONALD, Gregor, James; (GB).
STANWAY, Steven, James; (GB).
THOMPSON, Mervyn; (GB).
WESTAWAY, Susan, Marie; (GB)
Agent: GIDDINGS, Peter, John; GlaxoSmithKline, Corporate Intellectual Property (CN925.1), 980 Great West Road, Brentford, Middlesex TW8 9GS (GB)
Priority Data:
Title (EN) PIPERAZINE HETEROARYL DERIVATES AS GPR38 AGONISTS
(FR) DERIVÉS D’HÉTÉROARYLE PIPÉRAZINE EN TANT QU’AGONISTES GPR38
Abstract: front page image
(EN)The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, (I) wherein R1, R2, R3, R4, R5, R6, Z, X and B are as defined in the specification. The compounds are partial or full agonists at the GPR38 receptor. Pharmaceutical compositions comprising the compounds, methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
(FR)La présente invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci, (I) où R1, R2, R3, R4, R5, R6, Z, X et B sont tels que définis dans la description. Les composés sont des agonistes partiels ou complets au récepteur GPR38. La présente invention concerne également des compositions pharmaceutiques comprenant les composés, des procédés de préparation des composés, des utilisations des composés et des procédés impliquant les composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)