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1. (WO2007006732) SYNERGISTIC COMBINATION FOR THE TREATMENT OF PAIN (CANNABIOID RECEPTOR AGONIST AND OPIOD RECEPTOR AGONIST)
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006732 International Application No.: PCT/EP2006/063985
Publication Date: 18.01.2007 International Filing Date: 06.07.2006
IPC:
A61K 31/517 (2006.01) ,A61K 31/485 (2006.01) ,A61K 31/4468 (2006.01) ,A61K 31/135 (2006.01) ,A61P 25/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4468
having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
04
Centrally acting analgesics, e.g. opioids
Applicants:
N.V. ORGANON [NL/NL]; Kloosterstraat 6 NL-5349 AB Oss, NL (AllExceptUS)
ADAM-WORRALL, Julia [GB/GB]; GB (UsOnly)
HILL, David, Robert [GB/GB]; GB (UsOnly)
COTTNEY, Jean [GB/GB]; GB (UsOnly)
Inventors:
ADAM-WORRALL, Julia; GB
HILL, David, Robert; GB
COTTNEY, Jean; GB
Priority Data:
05106309.711.07.2005EP
Title (EN) SYNERGISTIC COMBINATION FOR THE TREATMENT OF PAIN (CANNABIOID RECEPTOR AGONIST AND OPIOD RECEPTOR AGONIST)
(FR) COMBINAISON SYNERGIQUE POUR TRAITER UNE DOULEUR (AGONISTE DU RECEPTEUR CANABINOIDE ET AGONISTE DU RECEPTEUR OPIOIDE)
Abstract:
(EN) The invention relates to a pharmaceutical dosage form comprising an analgesic combination for simultaneous or sequential use which comprises a peripherally restricted cannabinoid CB1 receptor agonist having a brain Cmax to plasma Cmax ratio of less than 0.1 and an opioid receptor agonist, as well as to a method for treating pain using said pharmaceutical dosage form.
(FR) L'invention concerne une forme dosifiée pharmaceutique comprenant une combinaison analgésique destinée à une utilisation simultanée ou séquentielle. Cette forme dosifiée comprend un agoniste du récepteur canabinoïde CB1 périphériquement restreint présentant un rapport Cmax cerveau sur Cmax plasma inférieur à 0,1, et un agoniste du récepteur opioïde. L'invention concerne également une méthode pour traiter un douleur à l'aide de cette forme dosifiée pharmaceutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1904068JP2009500439US20090029984CA2614528AU2006268680