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1. (WO2007006715) CYSTEINE PROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006715 International Application No.: PCT/EP2006/063951
Publication Date: 18.01.2007 International Filing Date: 06.07.2006
IPC:
C07D 491/04 (2006.01) ,A61K 31/5377 (2006.01) ,A61P 19/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
Applicants:
MEDIVIR AB [SE/SE]; Lunastigen 7 S-141 44 Huddinge, SE (AllExceptUS)
KANGASMETSA, Jussi [SE/GB]; GB (UsOnly)
LILEY, Mark [GB/GB]; GB (UsOnly)
Inventors:
KANGASMETSA, Jussi; GB
LILEY, Mark; GB
Agent:
TEUTEN, Andrew; Sagittarius IPC Ltd Taylor House 39 High Street Marlow Buckinghamshire SL7 1AF, GB
Priority Data:
0513840.907.07.2005GB
Title (EN) CYSTEINE PROTEASE INHIBITORS
(FR) INHIBITEURS DE CYSTEINE PROTEASE
Abstract:
(EN) Stereoisomers of the formula (III) wherein R is H or C1-C3 optionally halo-substituted alkyl; or pharmaceutically acceptable salts, hydrates or N-oxides thereof have utility in the treatment of disorders mediated by inappropriate expression or activation of cathepsin K, such as osteoporosis, osteoarthritis or bone metastases.
(FR) Stéréoisomères de formule (III), sachant que R est H ou alkyle C1-C3 éventuellement halo-substitué, y compris leurs sels, hydrates ou N-oxydes pharmaceutiquement acceptables, utiles pour le traitement de troubles dont la médiation est assurée par une expression ou activation inadéquate de la cathepsine K, du type ostéoporose, arthrose ou métastase osseuse.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)