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Machine translation
1. (WO2007006543) CAMPTOTHECIN ANALOGUES, PROCESS FOR THEIR PREPARATION, USE AND FORMULATIONS CONTAINING THEM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/006543    International Application No.:    PCT/EP2006/006760
Publication Date: 18.01.2007 International Filing Date: 11.07.2006
IPC:
C07D 471/14 (2006.01), A61K 31/435 (2006.01), A61P 35/00 (2006.01)
Applicants: INDENA S.p.A. [IT/IT]; Viale Ortles, 12, I-20139 Milano (IT) (For All Designated States Except US).
BOMBARDELLI, Ezio [IT/IT]; (IT) (For US Only).
FONTANA, Gabriele [IT/IT]; (IT) (For US Only)
Inventors: BOMBARDELLI, Ezio; (IT).
FONTANA, Gabriele; (IT)
Agent: BANFI, Paolo; Bianchetti Bracco Minoja S.r.l., Via Plinio, 63, I-20129 Milano (IT)
Priority Data:
MI2005A001348 14.07.2005 IT
Title (EN) CAMPTOTHECIN ANALOGUES, PROCESS FOR THEIR PREPARATION, USE AND FORMULATIONS CONTAINING THEM
(FR) ANALOGUES DE CAMPTOTHECINE, PROCEDE DE PREPARATION DE CEUX-CI, UTILISATION DE CEUX-CI AINSI QUE PREPARATIONS LES CONTENANT
Abstract: front page image
(EN)The present invention relates to novel camptothecin derivatives of general formula (I) in which R1 is a straight or branched polyamino residue, optionally functionalized by acylation or alkylation of the amino residues with more than 2 nitrogen atoms; R2 is H, -OR3; R3 is H or a straight or branched C1-C24 saturated or unsaturated acyl residue; R4 is H, straight or branched C1-C4 alkyl, hydroxyalkyl, aminoalkyl or cyano; R5 and R6 can be H, OH or OCH3. The compounds of the present invention can be conveniently administered for the therapy of tumors, in the form of suitable pharmaceutical formulations.
(FR)L'invention concerne de nouveaux dérivés de camptothécine de formule générale (I) dans laquelle R1 représente un résidu polyamino linéaire ou ramifié, éventuellement fonctionnalisé par acylation ou alkylation des résidus amino avec plus de deux atomes d'azote, R2 représente H, -OR3, R3 représente H ou un résidu acyle saturé ou non saturé C1-C24 linéaire ou ramifié, R4 représente H, alkyle C1-C4 linéaire ou ramifié, hydroxyalkyle, aminoalkyle ou cyano, R5 et R6 peuvent représenter H, OH ou OCH3. Les composés de cette invention peuvent être facilement administrés dans la thérapie de tumeurs, sous forme de préparations pharmaceutiques adaptées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)