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1. (WO2007006427) COILED WIRE FOR THE CONTROLLED RELEASE OF DUGS TO THE EYE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006427 International Application No.: PCT/EP2006/006355
Publication Date: 18.01.2007 International Filing Date: 30.06.2006
IPC:
A61L 31/10 (2006.01) ,A61F 2/14 (2006.01) ,A61K 9/50 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
08
Materials for coatings
10
Macromolecular materials
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02
Prostheses implantable into the body
14
Eye parts, e.g. lenses, corneal implants; Artificial eyes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
Applicants:
DSM IP ASSETS B.V. [NL/NL]; Het Overloon 1 NL-6411 Te Heerlen, NL (AllExceptUS)
DIAS, Aylvin, Jorge, Angelo, Athanasius [NL/NL]; NL (UsOnly)
KOOLE, Levinus, Hendrik [NL/NL]; NL (UsOnly)
PIJLS, Rachel, Theodora [NL/NL]; NL (UsOnly)
Inventors:
DIAS, Aylvin, Jorge, Angelo, Athanasius; NL
KOOLE, Levinus, Hendrik; NL
PIJLS, Rachel, Theodora; NL
Agent:
HABETS, W.J.A.; DSM Intellectual Property P.O. Box 9 6160 MA Geleen, NL
Priority Data:
05076580.911.07.2005EP
05077210.227.09.2005EP
Title (EN) COILED WIRE FOR THE CONTROLLED RELEASE OF DUGS TO THE EYE
(FR) FIL SPIRALE POUR LA LIBERATION CONTROLEE DE MEDICAMENTS DANS L'OEIL
Abstract:
(EN) This invention is in the area of medical devices, in particular in the area of medical devices for drug delivery, more in particular for controlled release of drugs to the eye. Delivery of drugs to the anterior side of the eye is routinely done with eye drops, but this method results in low bioavailability and low patient compliance. Devices that address these problems have been described for the delivery of drugs to the eye. One of such devices, called the OphthaCoil, consists of a thin metallic wire, which is coiled and carries a drug-loaded adherent hydrogel coating on its surface. Surprisingly it has now been found that the drug loading capacity can be dramatically increased by filling the lumen of the coil with micro-particles such as microspheres that contain the drug of choice.
(FR) L'invention concerne le domaine des dispositifs médicaux, en particulier le domaine des dispositifs médicaux pour la libération de médicaments, et plus particulièrement pour la libération contrôlée de médicaments dans l'oeil. La libération contrôlée de médicaments dans la face antérieure de l'oeil est effectuée de manière générale à l'aide d'un collyre, cette méthode présentant toutefois des résultats peu satisfaisants en matière de biodisponibilité et d'observance. Des dispositifs apportant des solutions à ces problèmes ont précédemment été décrits pour la libération de médicaments dans l'oeil. Un de ces dispositifs, appelé 'OphthaCoil', comprend un fil métallique fin spiralé sur la surface duquel est appliqué un revêtement d'hydrogel adhérent chargé par un médicament. De manière étonnante, il a été découvert que la capacité de chargement de médicament pouvait être considérablement augmentée par remplissage de la lumière du fil spiralé avec des microparticules de type microsphères contenant un médicament sélectionné.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1912686US20090143747