Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2007006391) CYNARA SCOLYMUS EXTRACTS, THE USE THEREOF ANS FORMULATIONS CONTAINING THEM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006391 International Application No.: PCT/EP2006/005778
Publication Date: 18.01.2007 International Filing Date: 16.06.2006
IPC:
A61K 36/28 (2006.01) ,A61P 1/00 (2006.01) ,A61P 3/06 (2006.01) ,A61P 9/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
28
Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants:
INDENA S.P.A. [IT/IT]; Viale Ortles, 12 I-20139 Milano, IT (AllExceptUS)
BOMBARDELLI, Ezio [IT/IT]; IT (UsOnly)
FONTANA, Gabriele [IT/IT]; IT (UsOnly)
GIORI, Andrea [IT/IT]; IT (UsOnly)
MORAZZONI, Paolo [IT/IT]; IT (UsOnly)
RONCHI, Massimo [IT/IT]; IT (UsOnly)
ARPINI, Sabrina [IT/IT]; IT (UsOnly)
Inventors:
BOMBARDELLI, Ezio; IT
FONTANA, Gabriele; IT
GIORI, Andrea; IT
MORAZZONI, Paolo; IT
RONCHI, Massimo; IT
ARPINI, Sabrina; IT
Agent:
MINOJA, Fabrizio. ; Bianchetti Bracco Minoja S.r.L. Via Plinio, 63 I-20129 Milano, IT
Priority Data:
MI2005A00134714.07.2005IT
Title (EN) CYNARA SCOLYMUS EXTRACTS, THE USE THEREOF ANS FORMULATIONS CONTAINING THEM
(FR) EXTRAITS DE CYNARA SCOLYMUS, LEUR UTILISATION ET FORMULATIONS LES CONTENANT
Abstract:
(EN) The present invention relates to the preparation of a Cynara scolymus extract obtainable by fractioning on a resin. The process of the invention allows to obtain an extract, starting from the aerial parts of the plant Cynara scolymus, containing three classes of active principles, namely dicaffeoylquinic acids, luteolin and cynaropicrin glycosides, in a constant ratio. Cynaropicrin is stabilized by addition of precise amounts of sulfated amino acids or suitable thio-derivatives. These extracts have hypolipemizing, anti-dyspeptic and vascular anti-inflammatory activities. The extracts are mainly formulated in Enothera biennis oil or in oils rich in &ohgr;-3 and &ohgr;-6 acids which enhance the vascular activity.
(FR) La présente invention concerne la préparation d'un extrait de Cynara scolymus pouvant être obtenu par fractionnement sur une résine. Le procédé de l'invention permet d'obtenir un extrait, à partir des parties aériennes de la plante Cynara scolymus, contenant trois classes de principes actifs, à savoir des acides dicafféoylquiniques, des glycosides de lutéoline et de cynaropicrine, dans un rapport constant. La cynaropicrine est stabilisée par addition de quantités précises d'acides aminés sulfatés ou de thio-dérivés appropriés. Ces extraits ont des activités vasculaires hypolipémiantes, antidyspeptiques et anti-inflammatoires. Les extraits sont principalement formulés dans l'huile d'Oenothera biennis ou dans des huiles riches en acides &ohgr;-3 et &ohgr;-6 qui améliorent l'activité vasculaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080198NZ565025KR1020080038127EP1906983JP2009501708US20090285911
CN101222931CA2614796AU2006269035IN160/KOLNP/2008