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1. (WO2007006319) INHIBITORS OF ANOREXIC LIPID HYDROLYSIS FOR THE TREATMENT OF EATING DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006319 International Application No.: PCT/DK2006/050030
Publication Date: 18.01.2007 International Filing Date: 14.07.2006
Chapter 2 Demand Filed: 14.05.2007
IPC:
A61K 31/165 (2006.01) ,A61K 31/047 (2006.01) ,A61P 3/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
047
having two or more hydroxy groups, e.g. sorbitol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
Applicants:
RHEOSCIENCE A/S [DK/DK]; Glerupvej 2 DK-2610 Rødovre, DK (AllExceptUS)
THE UNIVERSITY OF COPENHAGEN [DK/DK]; Universitetsparken 2 DK-2100 Copenhagen Ø, DK (AllExceptUS)
HANSEN, Harald, S. [DK/DK]; DK (UsOnly)
PETERSEN, Gitte [DK/DK]; DK (UsOnly)
ARTMANN, Andreas [DK/DK]; DK (UsOnly)
LARSEN, Philip, J. [DK/DK]; DK (UsOnly)
Inventors:
HANSEN, Harald, S.; DK
PETERSEN, Gitte; DK
ARTMANN, Andreas; DK
LARSEN, Philip, J.; DK
Agent:
SMART, Peter, J.; Beck Greener 12, Fulwood Place, London WC1V 6HR, GB
Priority Data:
60/699,98314.07.2005US
PA20050102914.07.2005DK
Title (EN) INHIBITORS OF ANOREXIC LIPID HYDROLYSIS FOR THE TREATMENT OF EATING DISORDERS
(FR) INHIBITEURS DE L'HYDROLYSE DES LIPIDES ANOREXIQUES POUR LE TRAITEMENT DES TROUBLES DE L'ALIMENTATION
Abstract:
(EN) Compounds, pharmaceuticals, cosmetic or dietary supplements for the treatment of overweight, obesity and/or type II diabetes in a mammal (e.g. human) comprising a compound with formula I or formula II for example ceramidase-inhibitor, such as (1S,2R)-D-erythro-2-(N-myristoylamino)-1- phenyl-1-propanol, alone or in combination with an anorexic lipid (or other appetite-inhibiting acylamides or oleoyl-estrone), and methods of treatment comprising administration of said compounds, pharmaceuticals, cosmetic or a dietary supplements. The compounds, pharmaceuticals, cosmetic or dietary supplements and methods of the invention may further be used in modifying the feeding behaviour, suppression of hunger, enhancement of satiety, reduction of energy intake, reduction of fat tissue mass/lean mass ratio in a mammal (e.g. human).
(FR) L'invention concerne des composés, des produits pharmaceutiques, des produits cosmétiques ou des compléments alimentaires destinés à traiter la surcharge pondérale, l'obésité et/ou le diabète de type 2 chez un mammifère (par exemple un humain), qui renferment un composé de formule (I) ou (II), par exemple un inhibiteur de céramidase, tel que (1S,2R)-D-érythro-2-(N-myristoylamino)-1-phényl-1-propanol, seul ou en association avec un lipide anorexique (ou d'autres acylamides ou oléoyle-estrone anorexigènes). De plus, l'invention concerne des méthodes de traitement qui consistent à administrer ces composés, produits pharmaceutiques, produits cosmétiques ou compléments alimentaires. Par ailleurs, les méthodes de traitement, les composés, les produits pharmaceutiques, les produits cosmétiques ou les compléments alimentaires de l'invention peuvent servir à modifier le comportement alimentaire, réduire la sensation de faim, augmenter la satiété, réduire le rapport énergétique, et réduire le rapport entre la masse grasse et la masse maigre chez un mammifère (par exemple, un humain).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1917007US20090054526CN101247797IN941/DELNP/2008