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1. (WO2007006230) PROCESS FOR PREPARING ERIANIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006230 International Application No.: PCT/CN2006/001649
Publication Date: 18.01.2007 International Filing Date: 12.07.2006
Chapter 2 Demand Filed: 30.12.2006
IPC:
C07C 41/20 (2006.01) ,C07C 43/253 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
41
Preparation of ethers; Preparation of compounds having groups, groups or groups
01
Preparation of ethers
18
by reactions not forming ether-oxygen bonds
20
by hydrogenation of carbon-to-carbon double or triple bonds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
43
Ethers; Compounds having groups, groups or groups
02
Ethers
235
having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring, other than a six-membered aromatic ring
253
containing hydroxy or O-metal groups
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
浙江赛尔生物医学研究有限公司 ZHE JIANG CELL BIOMEDICAL RESEARCH CO., LTD. [CN/CN]; 中国浙江省台州市天台县城关镇赤城路299号立钻大厦14楼, Zhejiang 317200 14th Floor Li Zuan Mansion, No.299 Chi Cheng Road Tian Tai Town Tai Zhou, Zhe Jian 317200, CN (AllExceptUS)
李亦平 LI, Yiping [US/CN]; CN (UsOnly)
刘双喜 LIU, Shuangxi [CN/CN]; CN (UsOnly)
Inventors:
李亦平 LI, Yiping; CN
刘双喜 LIU, Shuangxi; CN
Agent:
北京律诚同业知识产权代理有限公司 LECOME INTELLECTUAL PROPERTY AGENT LTD.; 中国北京市海淀区知春路甲48号盈都大厦B16层, Beijing 100098 Floor 16, Tower B INDO Mansion No. 48-JIA Zhichun Road Haidian District Beijing 100098, CN
Priority Data:
200510083055.413.07.2005CN
Title (EN) PROCESS FOR PREPARING ERIANIN
(FR) PROCÉDÉ DE PRÉPARATION D’ÉRIANINE
(ZH) 毛兰素的制备方法
Abstract:
(EN) The present invention relates to a process for preparing Erianin (Dihydro Combretastatin A-4), whererin 3,4,5-trimethoxy benzaldehyde is converted to phosphonium salt or phosphonate ester or the likes thereof, then reacted with isovanillin (3-hydroxyl-4-methoxyl benzaldehyde) having a protected hydroxy in the 3-position, followed by hydrogenation and deprotection.
(FR) La présente invention concerne un procédé de préparation d’Érianine (Dihydro Combretastatine A-4), le 3,4,5-triméthoxybenzaldéhyde étant converti en sel de phosphonium ou ester de phosphonate ou analogues de celui-ci puis mis en réaction avec de l’isovanilline (3-hydroxyl-4-méthoxylbenzaldéhyde) ayant un hydroxy protégé en position 3, suivi d’une hydrogénation et d’une déprotection.
(ZH) 本发明公开了一种毛兰素的制备方法。在该制备方法中,以3,4,5-三甲氧基苯甲醛和异香兰素为起始原料,主要通过成键反应、加氢反应等步骤,制备得到毛兰素。本发明首次采用化学合成方法制备毛兰素,其化学原料简便易得,所用试剂也较便宜,适宜工业规模生产。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
US20090018369