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1. (WO2007006212) TETRAHYDROPROTOBERBERINE COMPOUNDS, THE SYNTHETIC METHOD AND THE USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006212 International Application No.: PCT/CN2006/001601
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
Chapter 2 Demand Filed: 27.04.2007
IPC:
C07D 455/03 (2006.01) ,A61K 31/4375 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
455
Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
03
containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4375
the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
18
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants:
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SIENCES [CN/CN]; 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Pu dong New District Shanghai 201203, CN (AllExceptUS)
TOPHARMAN SHANGHAI CO., LTD. [CN/CN]; 1088 Chuansha Road Pudong New District Shanghai 201209, CN (AllExceptUS)
LI, Jianfeng [CN/CN]; CN (UsOnly)
LIU, Aixiang [CN/CN]; CN (UsOnly)
CHEN, Xinjian [CN/CN]; CN (UsOnly)
JIN, Guozhang [CN/CN]; CN (UsOnly)
YAN, Tiema [CN/CN]; CN (UsOnly)
ZHANG, Rongxia [CN/CN]; CN (UsOnly)
ZHU, Yi [CN/CN]; CN (UsOnly)
PAN, Yanjun [CN/CN]; CN (UsOnly)
SHEN, Jingshan [CN/CN]; CN (UsOnly)
SHEN, Jingkang [CN/CN]; CN (UsOnly)
Inventors:
LI, Jianfeng; CN
LIU, Aixiang; CN
CHEN, Xinjian; CN
JIN, Guozhang; CN
YAN, Tiema; CN
ZHANG, Rongxia; CN
ZHU, Yi; CN
PAN, Yanjun; CN
SHEN, Jingshan; CN
SHEN, Jingkang; CN
Agent:
KINGSOUND & PARTNERS; 11/F, Block B, KingSound International Center, 116 Zizhuyuan Road, Haidian District Beijing 100097, CN
Priority Data:
200510027630.908.07.2005CN
Title (EN) TETRAHYDROPROTOBERBERINE COMPOUNDS, THE SYNTHETIC METHOD AND THE USE THEREOF
(FR) COMPOSÉS TÉTRAHYDROPROTOBERBÉRINES, PROCÉDÉ DE SYNTHÈSE ET UTILISATION DE CEUX-CI
Abstract:
(EN) The present invention relates to tetraliydroprotoberberines of the formula (I) and the physiologically acceptable salts thereof. The invention also relates to the use of the compounds of the formula (I) or pharmaceutically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with dopamine receptor ligand, such as schizophrenia.
(FR) La présente invention concerne les tétrahydroprotoberbérines de formule (I) et leurs sels physiologiquement acceptables. L’invention a également trait à l’utilisation de composés de formule (I) ou de sels pharmaceutiquement acceptables de ceux-ci en vue de la préparation d’une composition pharmaceutique destinée au traitement des maladies susceptibles d’être traitées avec des ligands des récepteurs dopaminergiques, telles que la schizophrénie.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1904493US20090149488