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1. (WO2007006211) DIPEPTIDYL PEPTIDASE IV (DDP IV) INHIBITORS, PREPARATION METHODS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006211 International Application No.: PCT/CN2006/001596
Publication Date: 18.01.2007 International Filing Date: 06.07.2006
IPC:
C07D 495/14 (2006.01) ,C07D 471/14 (2006.01) ,C07D 491/048 (2006.01) ,A61K 31/519 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/10 (2006.01) ,A61P 19/10 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
044
with only one oxygen atom as ring hetero atom in the oxygen-containing ring
048
the oxygen-containing ring being five-membered
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国上海市浦东新区祖冲之路555号, Shanghai 201203 555 Zu Chong Zhi Road Pudong New District Shanghai 201203, CN (AllExceptUS)
李佳 LI, Jia [CN/CN]; CN (UsOnly)
南发俊 NAN, Fajun [CN/CN]; CN (UsOnly)
顾明 GU, Ming [CN/CN]; CN (UsOnly)
李静雅 LI, Jingya [CN/CN]; CN (UsOnly)
易华 YI, Hua [CN/CN]; CN (UsOnly)
李媛媛 LI, Yuanyuan [CN/CN]; CN (UsOnly)
Inventors:
李佳 LI, Jia; CN
南发俊 NAN, Fajun; CN
顾明 GU, Ming; CN
李静雅 LI, Jingya; CN
易华 YI, Hua; CN
李媛媛 LI, Yuanyuan; CN
Agent:
上海开祺知识产权代理有限公司 SHANGHAI KAIJI INTELLECTUAL PROPERTY AGENT CO., LTD.; 中国上海市南丹东路188号1501室, Shanghai 200030 Rm. 1501, 188 Nandandong Road Shanghai 200030, CN
Priority Data:
200510027629.608.07.2005CN
Title (EN) DIPEPTIDYL PEPTIDASE IV (DDP IV) INHIBITORS, PREPARATION METHODS AND USES THEREOF
(FR) INHIBITEURS DE DIPEPTIDYL PEPTIDASE IV (DDP IV), PROCÉDÉS DE PRÉPARATION ET UTILISATIONS DE CEUX-CI
(ZH) 一类二肽霉四抑制剂及其制备方法和应用
Abstract:
(EN) Dipeptidyl peptidase IV inhibitors of the following general formula are provided. And the said inhibitors are proved to be capable of effectively inhibiting the activity of DDPIV, and can be used for the prophylaxis, delay or treatment of the diseases mediated by DDPIV, especially diabetes type I and II, impaired glucose tolerance (IGT), obesity, arthritis, osteoporosis and some tumors. The preparation methods of the present inhibitors are also provided.(formula)
(FR) La présente invention concerne des inhibiteurs de dipeptidyl peptidase IV de la formule générale suivante. Il est prouvé que lesdits inhibiteurs sont capables d’inhiber efficacement l’activité de la DDP IV et peuvent être utiles dans la prophylaxie, le retardement ou le traitement des maladies médiées par le DDP IV, particulièrement les types I et I de diabète, la tolérance abaissée au glucose (IGT), l’obésité, l’arthrite, l’ostéoporose et certaines tumeurs. L’invention concerne également les procédés de préparation desdits inhibiteurs .
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)