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1. (WO2007006036) HYDROXYLATED FORMS OF ERGOSTEROLS AND ERGOCALCIFEROLS, DERIVATIVES THEREOF, METHODS OF PRODUCTION AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/006036 International Application No.: PCT/US2006/026476
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
A61K 31/54 (2006.01) ,C07C 401/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
54
having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
401
Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Applicants:
THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION [US/US]; 3 North Dunlap Memphis, TN 38163, US (AllExceptUS)
Inventors:
SLOMINSKI, Andrzej; US
TUCKEY, Robert; US
LI, Wei; US
ZBYTEK, Blazej; US
ZJAWIONY, Jordan; US
WORTSMAN, Jacobo; US
Agent:
ADLER, Benjamin, A.; Adler & Associates 8011 Candle Lane Houston, TX 77071, US
Priority Data:
60/696,62705.07.2005US
60/801,21617.05.2006US
Title (EN) HYDROXYLATED FORMS OF ERGOSTEROLS AND ERGOCALCIFEROLS, DERIVATIVES THEREOF, METHODS OF PRODUCTION AND USES THEREOF
(FR) FORMES HYDROXYLEES D'ERGOSTEROLS ET D'ERGOCALCIFEROLS, DERIVES DE CEUX-CI, PROCEDES DE PRODUCTION ET UTILISATIONS DE CEUX-CI
Abstract:
(EN) Provided herein is an enzymatic method of producing hydroxylated ergosterols and hydroxylated ergocalciferols using the cytochrome P450scc enzyme and/or the CYP27B1 enzyme and the hydroxylated compounds so produced. Also provided are methods of using the hydroxylated ergosterols and hydroxylated ergocalciferols to treat a tumor or other pathophysiologic condition.
(FR) Cette invention se rapporte à un procédé enzymatique de production d'ergostérols hydroxylés et d'ergocalciférols hydroxylés utilisant l'enzyme du cytochrome P450scc et/ou l'enzyme CYP27B1 et aux composés hydroxylés ainsi produits. Cette invention concerne également des procédés d'utilisation des ergostérols hydroxylés et des ergocalciférols hydroxylés pour traiter une tumeur ou un autre état pathologique.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)