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1. (WO2007006025) LEFTY, LEFTY DERIVATIVES AND USES THEROF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/006025    International Application No.:    PCT/US2006/026443
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
C07K 14/435 (2006.01)
Applicants: ACCELERON PHARMA INC. [US/US]; 24 Emily Street, Cambridge, MA 02139 (US) (For All Designated States Except US).
KNOPF, John [US/US]; (US) (For US Only).
SEEHRA, Jasbir [US/US]; (US) (For US Only).
KUMAR, Ravindra [US/US]; (US) (For US Only)
Inventors: KNOPF, John; (US).
SEEHRA, Jasbir; (US).
KUMAR, Ravindra; (US)
Agent: VINCENT, Matthew, P.; Fish & Neave IP Group, Ropes & Gray LLP, One International Place, Boston, MA 02110-2624 (US)
Priority Data:
60/696,226 01.07.2005 US
Title (EN) LEFTY, LEFTY DERIVATIVES AND USES THEROF
(FR) GENE LEFTY, DERIVES DU GENE LEFTY ET LEURS UTILISATIONS
Abstract: front page image
(EN)The disclosure relates to Lefty derivatives and the uses of Lefty polypeptides as antagonists of the function of certain ligands such as Nodal, GDF-8 (Myostatin), and GDF-11. These derivatives may be fused to other functional heterologous proteins such as IgG, especially the Fc portion of IgG. Accrording to the disclosure, Lefty polypeptides are useful in the treatment of a variety of disorders, including, for example, neuronal diseases, muscle and bone conditions, and metabolic disorders.
(FR)L'invention concerne des dérivés du gène Lefty et les utilisations de polypeptides de Lefty comme antagonistes de la fonction de certains ligands tels que Nodal, GDF-8 (myostatine) et GDF-11. Ces dérivés peuvent être combinés avec d'autres protéines hétérologues fonctionnelles telles que IgH, en particulier la partie Fc de IgG. Selon l'invention, les polypeptides de Lefty s'utilisent dans le traitement d'une variété de troubles, intégrant par exemple des maladies neuronales, des pathologies musculaires et osseuses et des troubles du métabolisme.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)