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1. (WO2007005995) COMPOSITIONS FOR BUCCAL DELIVERY OF HUMAN GROWTH HORMONE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005995 International Application No.: PCT/US2006/026262
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
A01N 37/18 (2006.01) ,A61K 38/00 (2006.01) ,C07H 21/04 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
37
Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
18
containing the group -CO-N, e.g. carboxylic acid amides or imides; Thio-analogues thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
Applicants:
EMISPHERE TECHNOLOGIES, INC. [US/US]; 765 Old Saw Mill River Road Tarrytown, NY 10591, US (AllExceptUS)
LIU, Puchun [US/US]; US (UsOnly)
DINH, Steven [US/US]; US (UsOnly)
LEE, Jongbin [US/US]; US (UsOnly)
Inventors:
LIU, Puchun; US
DINH, Steven; US
LEE, Jongbin; US
Agent:
LUDWIG, Peter, S. ; Darby & Darby P.C. P.O. Box 770 Church Street Station New York, NY 10008-0770, US
Priority Data:
60/697,01805.07.2005US
Title (EN) COMPOSITIONS FOR BUCCAL DELIVERY OF HUMAN GROWTH HORMONE
(FR) COMPOSITIONS POUR ADMINISTRATION PAR VOIE BUCCALE DE L'HORMONE DE CROISSANCE HUMAINE
Abstract:
(EN) The present invention provides pharmaceutical compositions for buccal delivery of human growth hormone (hGH) comprising a delivery agent and hGH. The compositions of the present invention provide improved delivery of hGH compared to comparable oral compositions, resulting in increased serum concentrations of hGH. The present inveniton further provides for methods of stimulating tissue growth in an animal by buccally co-administering hGH and a delivery agent.
(FR) La présente invention concerne des compositions pharmaceutiques utilisées pour administrer par voie buccale l'hormone de croissance humaine (HCH), ces compositions comprenant un agent d'administration et une HCH. Les compositions de l'invention permettent d'améliorer l'administration de la HCH comparé aux compositions analogues s'administrant par voie buccale, ce qui permet d'augmenter les concentrations de sérum de l'HCH. La présente invention concerne également des méthodes de stimulation de la croissance tissulaire chez un animal en coadministrant par voie buccale l'HCH et un agent d'administration.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20080207513