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1. (WO2007005991) INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN ALPHA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005991 International Application No.: PCT/US2006/026258
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
A61K 31/195 (2006.01) ,C07C 233/00 (2006.01) ,C07C 235/00 (2006.01) ,C07C 237/00 (2006.01) ,C07C 239/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
237
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
239
Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
Applicants:
TRUSTEES OF TUFTS COLLEGE [US/US]; 136 Harrison Avenue Boston, MA 02111, US (AllExceptUS)
BACHOVCHIN, William, W. [US/US]; US (UsOnly)
LAI, Hung-sen [US/US]; US (UsOnly)
Inventors:
BACHOVCHIN, William, W.; US
LAI, Hung-sen; US
Agent:
GORDON, Dana, M. ; PATENT GROUP FOLEY HOAG LLP 155 Seaport Boulevard Boston, MA 02210-2698, US
Priority Data:
60/696,77205.07.2005US
Title (EN) INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN ALPHA
(FR) INHIBITEURS DE PROTEINE ALPHA D'ACTIVATION DES FIBROBLASTES
Abstract:
(EN) Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic utilities, the peptide-based compounds may be useful for the treatment of cancer.
(FR) Cette invention concerne des composés à base de peptides qui comprennent de l'acide boronique ou une fonctionnalité cyano et qui inhibent efficacement et sélectivement la protéine alpha d'activation des fibroblastes. Parmi les utilisations thérapeutiques des composés à base de peptides figure notamment le traitement du cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080626MXMX/a/2008/000318KR1020080030079IL188327EP1898899BRPI0612607-3
JP2009500423US20090221818JP2012140439CN101247799IL217579CA2613795
AU2006264305IN602/CHENP/2008