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1. (WO2007005991) INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN ALPHA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005991    International Application No.:    PCT/US2006/026258
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
A61K 31/195 (2006.01), C07C 233/00 (2006.01), C07C 235/00 (2006.01), C07C 237/00 (2006.01), C07C 239/00 (2006.01)
Applicants: TRUSTEES OF TUFTS COLLEGE [US/US]; 136 Harrison Avenue, Boston, MA 02111 (US) (For All Designated States Except US).
BACHOVCHIN, William, W. [US/US]; (US) (For US Only).
LAI, Hung-sen [US/US]; (US) (For US Only)
Inventors: BACHOVCHIN, William, W.; (US).
LAI, Hung-sen; (US)
Agent: GORDON, Dana, M.; PATENT GROUP, FOLEY HOAG LLP, 155 Seaport Boulevard, Boston, MA 02210-2698 (US)
Priority Data:
60/696,772 05.07.2005 US
Title (EN) INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN ALPHA
(FR) INHIBITEURS DE PROTEINE ALPHA D'ACTIVATION DES FIBROBLASTES
Abstract: front page image
(EN)Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic utilities, the peptide-based compounds may be useful for the treatment of cancer.
(FR)Cette invention concerne des composés à base de peptides qui comprennent de l'acide boronique ou une fonctionnalité cyano et qui inhibent efficacement et sélectivement la protéine alpha d'activation des fibroblastes. Parmi les utilisations thérapeutiques des composés à base de peptides figure notamment le traitement du cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)