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1. (WO2007005988) PROCESS FOR PREPARING MALATHION FOR PHARMACEUTICAL USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005988    International Application No.:    PCT/US2006/026251
Publication Date: 11.01.2007 International Filing Date: 06.07.2006
IPC:
A01N 57/00 (2006.01), A61K 31/66 (2006.01)
Applicants: TARO PHARMACEUTICALS NORTH AMERICA, INC. [--/--]; P.O. Box 1034 GT Harbor Place 4th Floor, 103 South Church Street, Cayman, Cayman Island (KY) (For All Designated States Except US).
GUTMAN, Daniella [IL/IL]; (IL) (For US Only).
BAIDUSSI, Wael [IL/IL]; (IL) (For US Only)
Inventors: GUTMAN, Daniella; (IL).
BAIDUSSI, Wael; (IL)
Agent: GOLLIN, Michael, A.; Venable LLP, P.O. Box 34385, Washington, DC 20043-9998 (US)
Priority Data:
60/697,010 06.07.2005 US
60/741,360 01.12.2005 US
60/743,741 24.03.2006 US
Title (EN) PROCESS FOR PREPARING MALATHION FOR PHARMACEUTICAL USE
(FR) PROCEDE DE PREPARATION DE MALATHION DESTINE A UN USAGE PHARMACEUTIQUE
Abstract: front page image
(EN)The present invention provides a process for preparing a highly pure form of malathion having a reduced level of toxic impurities. In addition, the malathion prepared by the process of this invention is storage stable. The level of toxic impurities in the malathion, e.g., isomalathion, O,O,S-trimethyl phosphorodithioate (MeOOSPS), O, O, S-trimethyl phosphorothioate (MeOOSPO), O,S,S-trimethyl phosphorodithioate (MeOSSPO), malaoxon, isomalathion, diethyl fumarate, methyl malathion, dimethyl malathion, O,O-methyl, ethyl-S-(1,2-dicarboethoxy)ethyl-phosphorodithioate arse lower than that of any other commercial preparation of malathion that may be used for pharmaceutical purposes.
(FR)L'invention concerne un procédé pour préparer une forme de malathion présentant un degré de pureté extrêmement élevé et un niveau réduit d'impuretés toxiques. De plus, le malathion préparé au moyen du procédé selon l'invention est stable au stockage. Le niveau d'impuretés toxiques contenues dans le malathion, par ex. dans les composés isomalathion, O,O,S-triméthyl phosphorodithioate (MeOOSPS), O,O,S-triméthyl phosphorothioate (MeOOSPO), O,S,S-triméthyl phosphorodithioate (MeOSSPO), malaoxon, isomalathion, fumarate de diéthyle, malathion de méthyle, malathion de diméthyle, O,O-méthyl,éthyl-S-(1,2-dicarboéthoxy)éthyl-phosphorodithioate est inférieur à celui de toute autre préparation commerciale de malathion pouvant être utilisée à des fins pharmaceutiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)