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1. (WO2007005972) PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005972 International Application No.: PCT/US2006/026210
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
Chapter 2 Demand Filed: 24.01.2007
IPC:
C07D 401/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
Applicants:
CELGENE CORPORATION [US/US]; 86 Morris Avenue Summit, NJ 07901, US (AllExceptUS)
MULLER, George, W. [US/US]; US (UsOnly)
SAINDANE, Manohar, T. [US/US]; US (UsOnly)
GE, Chuansheng [US/US]; US (UsOnly)
CHEN, Roger [US/US]; US (UsOnly)
Inventors:
MULLER, George, W.; US
SAINDANE, Manohar, T.; US
GE, Chuansheng; US
CHEN, Roger; US
Agent:
INSOGNA, Anthony, M. ; JONES DAY 222 East 41st Street New York, NY 10017-6702, US
Priority Data:
60/696,22430.06.2005US
Title (EN) PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS
(FR) ELABORATION DE COMPOSES 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONIQUES
Abstract:
(EN) The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione compounds which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-&agr;. The invention can provide improved and/or efficient processes for the commercial production of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione compounds, including, but not limited to, unsubstituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione.
(FR) La présente invention concerne des procédés pour l'élaboration de composés 4-amino-2-(2,6-dioxopipéridin-3-yl)isoindoline-l,3-dioniques, éventuellement substitués. Ces composés conviennent particulièrement à la prévention ou au traitement d'affections ou d'états en lien ave un niveau anormalement élevé d'actifité du TNF-a. L'invention concerne également des procédés améliorés et/ou efficaces de production commerciale de composés 4-amino-2-(2,6-dioxopipéridin-3-yl)isoindoline-l,3-dioniques substitués et non substitués, et notamment de 4-amino-2-(2,6-dioxopipéridin-3-yl)isoindoline-l,3-dione non substitué.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
RSP-2013/0103MXMX/a/2007/016290KR1020080039392IL188330PE2007-0103EP1907373
CR123/9697ZA2008/00828JP2008544993EP2380887IL214892JP2013014599
BRPI0612803CN101253163CN102643267CA2612612CA2823088ES2430545
PT2380887PT1907373KR1020130029442NZ565309AU2006265019DK1907373
DK2380887AU2011221383ID048.1191ID2015/05326IN502/CHENP/2008IN2658/CHENP/2015