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1. (WO2007005965) PURIFICATION OF MONTELUKAST
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005965 International Application No.: PCT/US2006/026192
Publication Date: 11.01.2007 International Filing Date: 05.07.2006
IPC:
C07D 215/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Halogen atoms or nitro radicals
Applicants:
TEVA PAHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 Basel Street P.O. Box 3190 49131 Petah Tiqva, IL (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
TEVA PHARAMCEUTICAL USA, INC. [US/US]; 1090 Horsham Road P.O.Box 1090 North Wales, Pennsylvania 19454, US (BB)
STERIMBAUM, Greta [IL/IL]; IL (UsOnly)
SHAPIRO, Evgeny [IL/IL]; IL (UsOnly)
CHEN, Kobi [IL/IL]; IL (UsOnly)
Inventors:
STERIMBAUM, Greta; IL
SHAPIRO, Evgeny; IL
CHEN, Kobi; IL
Agent:
BRAINARD, Charles, R. ; Kenyon & Kenyon LLP One Broadway New York, NY 10004-1050, US
Priority Data:
60/697,00005.07.2005US
Title (EN) PURIFICATION OF MONTELUKAST
(FR) PURIFICATION DU MONTÉLUKAST
Abstract:
(EN) The present invention provides methods of purifying montelukast, a new isolated impurity of montelukast of formula I, method for its isolation, and method of using montelukast impurity as a reference marker and a reference standard.
(FR) La présente invention concerne des méthodes de purification du montélukast, une nouvelle impureté isolée dans le montélukast de formule I, une méthode d'isolement de ladite impureté, et une méthode d’emploi de l'impureté du montélukast au titre de marqueur de référence et d'étalon de référence.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2007/002609KR1020070088504KR1020090015186IL185731EP1904448JP2008510840
ES2358923CN101213177CA2608369ID048.1592IN9336/DELNP/2007