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1. WO2007005940 - COMBINATIONS OF ESZOPICLONE AND DIDESMETHYLSIBUTRAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS

Publication Number WO/2007/005940
Publication Date 11.01.2007
International Application No. PCT/US2006/026146
International Filing Date 05.07.2006
IPC
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48
having rings with two nitrogen atoms as the only ring hetero atoms
58
1,2-Diazines; Hydrogenated 1,2-diazines
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
48
having rings with two nitrogen atoms as the only ring hetero atoms
60
1,4-Diazines; Hydrogenated 1,4-diazines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
A01N 43/58 (2006.01)
A01N 43/60 (2006.01)
A61K 31/495 (2006.01)
A61K 31/50 (2006.01)
CPC
A61K 31/135
A61K 31/498
Applicants
  • SEPRACOR INC. [US/US]; 84 Waterford Drive Marlborough, Massachusetts 01752, US (AllExceptUS)
  • CARON, Judy [US/US]; US (UsOnly)
  • WESSEL, Thomas [US/US]; US (UsOnly)
  • LALJI, Karim [US/US]; US (UsOnly)
  • VARNEY, Mark A. [US/US]; US (UsOnly)
Inventors
  • CARON, Judy; US
  • WESSEL, Thomas; US
  • LALJI, Karim; US
  • VARNEY, Mark A.; US
Agents
  • TIMMER, Edward; HESLIN ROTHENBERG FARLEY & MESITI P.C. 5 Columbia Circle Albany, New York 12203, US
Priority Data
60/696,88006.07.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATIONS OF ESZOPICLONE AND DIDESMETHYLSIBUTRAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS
(FR) COMBINAISONS D'ESZOPICLONE ET DE DIDESMETHYLSIBUTRAMINE, METHODES DE TRAITEMENT DE LA MENOPAUSE, DE L'HUMEUR, DE L'ANXIETE ET DES TROUBLES DE LA CONNAISSANCE
Abstract
(EN)
One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is didesmethylsibutramine or (S)-didesmethylsibutramine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
(FR)
Un aspect de la présente invention concerne des compositions pharmaceutiques contenant au moins deux agents actifs qui, lorsqu'ils sont pris ensemble, peuvent être utilisés pour traiter, par exemple, la ménopause, les troubles de l'humeur, les troubles anxieux ou les troubles de la connaissance. Le premier constituant de la composition pharmaceutique est un eszopiclone sédatif. Le deuxième constituant de la composition pharmaceutique est la didesméthylsibutramine ou (S)-didesméthylsibutramine. Cette invention porte également sur une méthode de traitement de la ménopause, de la périménopause, des troubles de l'humeur, des troubles anxieux et des troubles de la connaissance.
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