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1. (WO2007005935) NOREPINEPHRINE TRANSPORTER RADIOTRACERS AND METHODS OF SYNTHESES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005935 International Application No.: PCT/US2006/026138
Publication Date: 11.01.2007 International Filing Date: 06.07.2006
IPC:
C07D 265/30 (2006.01) ,A61P 25/22 (2006.01) ,A61K 31/5375 (2006.01) ,A61P 25/24 (2006.01) ,A61K 51/04 (2006.01) ,A61P 25/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
265
Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
28
1,4-Oxazines; Hydrogenated 1,4-oxazines
30
not condensed with other rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
30
for treating abuse or dependence
Applicants:
MOLECULAR NEUROIMAGING, LLC [US/US]; 60 Temple Street Suite 8a New Haven, CT 06510, US (AllExceptUS)
TAMAGNAN, Gilles, D. [FR/US]; US (UsOnly)
ALAGILLE, David [FR/US]; US (UsOnly)
Inventors:
TAMAGNAN, Gilles, D.; US
ALAGILLE, David; US
Agent:
HEINE, Holliday, C. ; Weingarten, Schurgin, Gagnebin & Lebovici, LLP Ten Post Office Square Boston, MA 02109, US
Priority Data:
60/696,97906.07.2005US
Title (EN) NOREPINEPHRINE TRANSPORTER RADIOTRACERS AND METHODS OF SYNTHESES THEREOF
(FR) RADIOTRACEURS DE TRANSPORTEUR DE NOREPINEPHRINE ET PROCEDES RELATIFS A LEURS SYNTHESES
Abstract:
(EN) The present invention provides compounds and radiotracers thereof for locating, diagnosing, identifying, evaluating, detecting or quantitating NET by in vivo imaging. The invention also provides methods for locating, diagnosing, identifying, evaluating, detecting or quantitating NET, using radiotracers of high-affinity or labeled compounds of the invention, which exhibit low toxicity, can cross the blood-brain barrier and, preferably, distinguish among normal and abnormal brains. For example, a radiotracer of the invention can be administered to a patient in an amount suitable for in vivo imaging thereof. Preferably, radiotracers of the invention can also be used to locate, diagnosis, identify, evaluate, detect and quantitate NET in such diseases, disorders, conditions or maladies as, without limitation, depression, anxiety, ADHD and drug dependency.
(FR) Composés et radiotraceurs correspondants permettant de localiser, de diagnostiquer, d'identifier, d'évaluer, de détecter ou de quantifier les transporteurs de norépinéphrine (NET) par imagerie in vivo. Egalement, procédés permettant de localiser, de diagnostiquer, d'identifier, d'évaluer, de détecter ou de quantifier les NET, par le biais de radiotraceurs à haute affinité ou de composés marqués décrits, qui présentent une faible toxicité, capables de traverser la barrière hémato-encéphalique, et de préférence de faire la distinction entre cerveaux normaux et anormaux. Par exemple, un radiotraceur de ce type peut être administré en quantité appropriée à l'imagerie in vivo correspondante. De préférence, de tels radiotraceurs peuvent aussi être utilisés pour localiser, diagnostiquer, identifier, évaluer, détecter ou quantifier les NET en liaison avec des maladies du type, entre autres, dépression, anxiété, THADA et pharmacodépendance.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)