WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007005934) CONSTRAINED HIV ENVELOPE-BASED IMMUNOGEN THAT SIMULTANEOUSLY PRESENTS RECEPTOR AND CORECEPTOR BINDING SITES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005934    International Application No.:    PCT/US2006/026136
Publication Date: 11.01.2007 International Filing Date: 06.07.2006
IPC:
A61K 39/00 (2006.01), A61K 39/21 (2006.01), A61K 39/12 (2006.01), C12N 7/00 (2006.01), C12N 7/01 (2006.01), C07K 1/00 (2006.01), C07K 14/00 (2006.01)
Applicants: UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE [US/US]; 701 E. Pratt Street, Suite 200, Baltimore, MD 21202 (US) (For All Designated States Except US).
DEVICO, Anthony, L. [US/US]; (US) (For US Only).
LEWIS, George [US/US]; (US) (For US Only).
WANG, Lai-Xi [US/US]; (US) (For US Only)
Inventors: DEVICO, Anthony, L.; (US).
LEWIS, George; (US).
WANG, Lai-Xi; (US)
Agent: FUIERER, Marianne; Moore & Van Allen, PLLC, P.O. Box 13706, Research Triangle Park, NC 27709 (US)
Priority Data:
60/697,051 06.07.2005 US
Title (EN) CONSTRAINED HIV ENVELOPE-BASED IMMUNOGEN THAT SIMULTANEOUSLY PRESENTS RECEPTOR AND CORECEPTOR BINDING SITES
(FR) IMMUNOGENE A BASE D'ENVELOPPE DE VIH DE TYPE LIMITE PRESENTANT SIMULTANEMENT DES SITES DE LIAISON DE RECEPTEUR ET DE CO-RECEPTEUR
Abstract: front page image
(EN)The present invention relates to a soluble binding complex comprising a soluble gp120 trimer, in which only two gp120 protomers have CD4 binding sites occupied by interconnecting CD4 mimetic moieties, thereby allowing for the exposure of CD4-induced epitopes on the mimetic-bound protomers and an unoccupied CD4 binding site on the third gp120 protomer.
(FR)Complexe de liaison soluble comprenant un trimère gp120 soluble, dans lequel seulement deux protomères gp120 ont des sites de liaison CD4 occupés par des fractions mimétiques CD4 d'interconnexion, ce qui permet d'exposer des épitopes à induction CD4 sur les protomères à liaison mimétique et un site de liaison CD4 non occupé sur le troisième protomère gp120.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)