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1. (WO2007005874) HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH LIGAND 1 (PD-L1)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005874    International Application No.:    PCT/US2006/026046
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
IPC:
C07K 16/28 (2006.01)
Applicants: MEDAREX, INC. [US/US]; 707 State Road, Princeton, NJ 08540 (US) (For All Designated States Except US).
KORMAN, Alan, J. [US/US]; (US) (For US Only).
SELBY, Mark, J. [US/US]; (US) (For US Only).
WANG, Changyu [US/US]; (US) (For US Only).
SRINIVASAN, Mohan [IN/US]; (US) (For US Only).
PASSMORE, David, B. [US/US]; (US) (For US Only).
HUANG, Haichun [US/US]; (US) (For US Only).
CHEN, Haibin [CN/US]; (US) (For US Only)
Inventors: KORMAN, Alan, J.; (US).
SELBY, Mark, J.; (US).
WANG, Changyu; (US).
SRINIVASAN, Mohan; (US).
PASSMORE, David, B.; (US).
HUANG, Haichun; (US).
CHEN, Haibin; (US)
Agent: FEHLNER, Paul, L.; Baker Botts L.L.P., 30 Rockefeller Plaza, New York, NY 10012-4498 (US)
Priority Data:
60/696,426 01.07.2005 US
Title (EN) HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH LIGAND 1 (PD-L1)
(FR) ANTICORPS MONOCLONAUX HUMAINS DIRIGES CONTRE UN LIGAND DE MORT PROGRAMMEE DE TYPE 1(PD-L1)
Abstract: front page image
(EN)The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-Ll with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-Ll, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-Ll antibodies.
(FR)La présente invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains qui se lient spécifiquement à PD-L1 avec une affinité élevée. L'invention concerne également des molécules d'acides nucléiques codant pour les anticorps de l'invention, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps de l'invention. L'invention concerne en outre des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de l'invention. L'invention concerne enfin des méthodes de détection de PD-L1, ainsi que des méthodes de traitement de diverses maladies, notamment du cancer et de maladies infectieuses, à l'aide d'anticorps anti-PD-L1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)