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1. (WO2007005668) BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005668    International Application No.:    PCT/US2006/025699
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
IPC:
C07D 409/12 (2006.01), C07D 333/38 (2006.01), C07D 401/10 (2006.01), C07D 401/12 (2006.01), C07D 215/20 (2006.01), C07D 215/04 (2006.01), C07D 417/12 (2006.01), A61K 31/381 (2006.01), A61K 31/4725 (2006.01), A61K 31/416 (2006.01), A61K 31/4035 (2006.01), A61P 35/00 (2006.01)
Applicants: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
KIM, Tae-Seong [US/US]; (US) (For US Only).
HARMANGE, Jean-Christophe [FR/US]; (US) (For US Only).
BOOKER, Shon [US/US]; (US) (For US Only).
D'ANGELO, Noel [US/US]; (US) (For US Only).
DOMINGUEZ, Celia [US/US]; (US) (For US Only).
FELLOWS, Ingrid, M. [US/US]; (US) (For US Only).
LIU, Longbin [US/US]; (US) (For US Only).
TASKER, Andrew [GB/US]; (US) (For US Only).
BELLON, Steven [US/US]; (US) (For US Only).
HARVEY, Timothy, S. [GB/US]; (US) (For US Only).
LEE, Matthew [US/US]; (US) (For US Only).
GERMAIN, Julie [CA/US]; (US) (For US Only).
PATEL, Vinod, F. [US/US]; (US) (For US Only).
KIM, Joseph, L. [US/US]; (US) (For US Only)
Inventors: KIM, Tae-Seong; (US).
HARMANGE, Jean-Christophe; (US).
BOOKER, Shon; (US).
D'ANGELO, Noel; (US).
DOMINGUEZ, Celia; (US).
FELLOWS, Ingrid, M.; (US).
LIU, Longbin; (US).
TASKER, Andrew; (US).
BELLON, Steven; (US).
HARVEY, Timothy, S.; (US).
LEE, Matthew; (US).
GERMAIN, Julie; (US).
PATEL, Vinod, F.; (US).
KIM, Joseph, L.; (US)
Agent: HERMENAU, Ronald, S.; Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080 (US)
Priority Data:
60/696,389 30.06.2005 US
Title (EN) BIS-ARYL KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF INFLAMMATION, ANGIOGENESIS AND CANCER
(FR) INHIBITEURS DE BIS-ARYL KINASE ET METHODE ASSOCIEE
Abstract: front page image
(EN)Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
(FR)Selon l'invention, des composés sélectionnés sont efficaces dans la prophylaxie et le traitement de maladies, telles que des maladies à médiation HGF. Cette invention a aussi pour objet de nouveaux composés, analogues, promédicaments et sels correspondants acceptables pharmaceutiquement, des compositions pharmaceutiques et des méthodes de prophylaxie et de traitement de maladies ou d'autres troubles engendrant un cancer et similaire. Ladite invention a, également, trait à des processus de fabrication de tels composés, ainsi que d'intermédiaires utilisés dans ces processus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)