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1. (WO2007005643) NOVEL ARYLOXYPHENYLPROPANAMINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005643    International Application No.:    PCT/US2006/025651
Publication Date: 11.01.2007 International Filing Date: 30.06.2006
Chapter 2 Demand Filed:    01.02.2007    
IPC:
A01N 43/40 (2006.01), A61K 31/44 (2006.01)
Applicants: CONCERT PHARMACEUTICALS INC. [--/US]; 99 Hayden Ave, Suite 100, Lexington, MA 02421 (US) (For All Designated States Except US).
TUNG, Roger [US/US]; (US) (For US Only)
Inventors: TUNG, Roger; (US)
Agent: HSI, Jeffrey, D.; Edwards Angell Palmer & Dodge LLP, P.O. Box 55874, Boston, MA 02205 (US)
Priority Data:
60/696,211 01.07.2005 US
Title (EN) NOVEL ARYLOXYPHENYLPROPANAMINES
(FR) NOUVEAUX ARYLOXYPHENYLPROPANAMINES
Abstract: front page image
(EN)The present invention relates to a non-radioactive, heavy-atom isotopologue of Compound 1 containing one or more deuterium in place of a hydrogen covalently bound to carbon. The Compound 1 isotopologues of the invention are inhibitors of norepinephrine uptake and possess unique biopharmaceutical and pharmacokinetic properties compared to the corresponding non-isotope containing compounds. They may also be used to accurately determine the concentration of Compound 1 in biological fluids. The invention further provides compositions comprising these heavy-atom Compound 1 isotopologue and methods of treating diseases and conditions linked to reduced neurotransmission of norepinephrine.
(FR)La présente invention concerne un isotopologue à atomes lourds, non radioactif du composé 1 contenant au moins un deutérium à la place d'un hydrogène lié de manière covalente à un carbone. Les isotopologues du composé 1 de ladite invention constituent des inhibiteurs de recaptage de la norépinéphrine et possèdent des propriétés biopharmaceutiques et pharmacocinétiques uniques en comparaison avec les composés associés ne contenant pas d'isotopes. Ils peuvent, également, être utilisés pour déterminer avec précision la concentration du composé 1 dans des fluides biologiques. Ladite invention a aussi pour objet des compositions contenant ces isotopologues du composé 1 à atomes lourds et des méthodes de traitement de maladies et de troubles liés à la neurotransmission réduite de la norépinéphrine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)