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1. (WO2007005627) TUBERCULOSIS ANTIGEN DETECTION ASSAYS AND VACCINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005627 International Application No.: PCT/US2006/025620
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
IPC:
C07K 14/35 (2006.01) ,C12Q 1/68 (2006.01) ,A61K 39/04 (2006.01) ,G01N 33/569 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
35
from Mycobacteriaceae (F)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
04
Mycobacterium, e.g. Mycobacterium tuberculosis
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
FORSYTH DENTAL INFIRMARY FOR CHILDREN [US/US]; 140 The Fenway Boston, MA 02115, US (AllExceptUS)
CAMPOS-NETO, Antonio [BR/US]; US (UsOnly)
KASHINO, Suely, S. [BR/US]; US (UsOnly)
Inventors:
CAMPOS-NETO, Antonio; US
KASHINO, Suely, S.; US
Agent:
GIUGLIANO, Antoinette, G.; Antoinette G. Giugliano, P.C. 390 Salem Street Lynnfield, MA 01940, US
Priority Data:
60/696,43901.07.2005US
60/717,06214.09.2005US
Title (EN) TUBERCULOSIS ANTIGEN DETECTION ASSAYS AND VACCINES
(FR) ESSAIS DE DETECTION D'ANTIGENES DE LA TUBERCULOSE ET VACCINS
Abstract:
(EN) The present invention relates to isolated Tuberculosis (TB) antigens that are useful in therapeutic and vaccine compositions for stimulating a TB specific immunological response. The identified antigens are also useful in diagnostic assays to determine the presence of active TB in an individual. Accordingly, the present invention includes polypeptide molecules, nucleic acid molecules, vaccine compositions, diagnostic assays, and methods of diagnosis and monitoring treatment related to these TB antigens.
(FR) La présente invention se rapporte à des antigènes isolés de la Tuberculose (TB) qui sont utilisés dans des compositions thérapeutiques et vaccinales pour stimuler une réponse immunologique spécifique de la Tuberculose. Les antigènes identifiés sont également utilisés dans des essais diagnostiques pour déterminer la présence de Tuberculose active chez un individu. Ainsi, cette invention concerne des molécules de polypeptides, des molécules d'acides nucléiques, des compositions vaccinales, des essais diagnostiques et des méthodes de diagnostic et de surveillance d'un traitement associé à ces antigènes de la tuberculose.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1910410EP2305701BRPI0613168-9ZA2008/00401CN101365714IN5070/KOLNP/2007