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1. (WO2007005609) SYNTHESIS OF LABELED COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005609 International Application No.: PCT/US2006/025585
Publication Date: 11.01.2007 International Filing Date: 28.06.2006
Chapter 2 Demand Filed: 26.01.2007
IPC:
C07F 7/22 (2006.01) ,C07C 391/02 (2006.01) ,C07F 7/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
22
Tin compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
391
Compounds containing selenium
02
having selenium atoms bound to carbon atoms of six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
Applicants:
LOS ALAMOS NATIONAL SECURITY, LLC [US/US]; Los Alamos National Laboratory LC/IP MS A187 Los Alamos, NM 87545, US
Inventors:
MARTINEZ, Rodolfo, A.; US
SCHMIDT, Jurgen, G.; US
ALVAREZ, Marc, A.; US
SILKS, Louis, A., III; US
Agent:
COTTRELL, Bruce, H. ; Los Alamos National Laboratory LC/IP MS A187 Los Alamos, NM 87545, US
Priority Data:
11/172,12629.06.2005US
Title (EN) SYNTHESIS OF LABELED COMPOUNDS
(FR) SYNTHESE DE COMPOSES MARQUES
Abstract:
(EN) The present invention is directed to labeled compounds of the formula Ar-Zi-Q- Z2 where Ar is an aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure (I) wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, a phenyl, an alkoxy group and an amino group from the group consisting of NH2, NHR and NRR' where R and R' are each a C1-C4 lower alkyl, Q is selected from the group consisting of 13CH2, 13CDH and 13CD2, and Z1 is selected from the group consisting of -S-, -S(=O)-, -S(=O)2-, -Se-, -Se(=O)-, and -Se(=O)2-, Z2 is selected from the group consisting of -Si(R6R7R8), -O(R9), -Se-Ar, -Se(=O)2-Ar, -Se(=O)2-Ar, -S-Ar, -S(=O)-Ar, and -S(=O)2-Ar wherein R6, R7 and R8 are each independently selected from the group consisting of a C1-C4 lower alkyl, R9 is a C1-C4 lower alkyl or an R10-Ar group where R10 is a C1-C4 alkylene group.
(FR) Composés marqués de formule Ar-Zi-Q- Z2 : Ar est un groupe aryle qui peut être 1-naphtyle, 1-naphtyle substitué, 2-naphtyle, 2-naphtyle substitué, et groupes phényle avec la structure (I) sachant que R1, R2, R3, R4 et R5 sont chacun indépendamment hydrogène, C1-C4 alkyle inférieur, halogène, phényle, groupe alcoxy et groupe amino pouvant être NH2, NHR et NRR', avec R et R' chacun C1-C4 alkyle inférieur ; Q peut être 13CH2, 13CDH et 13CD2, Z1 peut être -S-, -S(=O)-, -S(=O)2-, -Se-, -Se(=O)-, et -Se(=O)2-, et Z2 peut être -Si(R6R7R8), -O(R9), -Se-Ar, -Se(=O)2-Ar, -Se(=O)2-Ar, -S-Ar, -S(=O)-Ar, et -S(=O)2-Ar, sachant que R6, R7 et R8 peuvent être chacun indépendamment C1-C4 alkyle inférieur, que R9 est C1-C4 alkyle inférieur ou un groupe R10-Ar, avec R10 comme groupe C1-C4 alkylène.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)