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1. (WO2007005608) IL-12/P40 BINDING PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/005608 International Application No.: PCT/US2006/025584
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
Chapter 2 Demand Filed: 29.01.2007
IPC:
C07K 16/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
Applicants:
ABBOTT LABORATORIES [US/US]; 100 Abbott Park Road Abbott Park, IL 60064, US (AllExceptUS)
LACY, Susan E. [CA/US]; US (UsOnly)
FUNG, Emma [CA/US]; US (UsOnly)
BELK, Jonathan P. [US/US]; US (UsOnly)
DIXON, Richard W. [US/US]; US (UsOnly)
ROGUSKA, Michael [US/US]; US (UsOnly)
HINTON, Paul R. [US/US]; US (UsOnly)
KUMAR, Shankar [US/US]; US (UsOnly)
Inventors:
LACY, Susan E.; US
FUNG, Emma; US
BELK, Jonathan P.; US
DIXON, Richard W.; US
ROGUSKA, Michael; US
HINTON, Paul R.; US
KUMAR, Shankar; US
Agent:
SESHADRI, Tara; Abbott Bioresearch Center 100 Research Drive Worcester, MA 01605-4314 , US
Priority Data:
60/695,67930.06.2005US
Title (EN) IL-12/P40 BINDING PROTEINS
(FR) PROTEINES DE LIAISON A L'IL-12/P40
Abstract:
(EN) The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.
(FR) La présente invention concerne des protéines de liaison à l'IL-12p40, en particulier des anticorps qui se lient à l'interleukine-12 humaine (hIL-12) et/ou à l'interleukine-23 humaine (hIL-23). Cette invention concerne spécifiquement des anticorps qui sont des anticorps chimères, à greffage de CDR et humanisés. Des anticorps préférés présentent une forte affinité pour l'interleukine-12 humaine et/ou l'interleukine-23 humaine et neutralisent l'activité de l'interleukine-12 humaine et/ou de l'interleukine-23 humaine in vitro et in vivo. Un anticorps de cette invention peut être un anticorps complet ou une partie de liaison à l'antigène de celui-ci. Cette invention concerne également un procédé de production et un procédé d'utilisation des anticorps de cette invention. Les anticorps ou les parties d'anticorps de cette invention servent à détecter l'interleukine-12 humaine et/ou l'interleukine-23 humaine et à inhiber l'activité de l'interleukine-12 humaine et/ou de l'interleukine-23 humaine, par exemple chez un sujet humain souffrant d'un trouble dans lequel l'activité de l'interleukine-12 humaine et/ou de l'interleukine-23 humaine est nuisible.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
BYa20080099NO20080557NZ563241MXMX/a/2007/016401KR1020080028895IL187691
SG163559VN19056EP1907421CR108/9599JP2009500018IL216803
RU0002461571CN101379085CN103145837CN103145838CN103145839CN103146708
CN103145840CN103145841CN103145842CN103172737CN103172738CN103172739
CA2612239CA2848662JP2013177405CR98/20130149CR98/20130150CR98/20130151
CR98/20130152CR98/20130153CR98/20130154CR98/20130155CR98/20130156CR98/20130157
KR1020130080058NZ596992AU2006265932AU2012238334VN25850VN25851
ID048.3598IN9729/DELNP/2007