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Machine translation
1. (WO2007005596) PRODUCTION OF CPD GLYCOSYLASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/005596    International Application No.:    PCT/US2006/025561
Publication Date: 11.01.2007 International Filing Date: 29.06.2006
IPC:
C12N 9/00 (2006.01), C12N 9/24 (2006.01), C12N 1/12 (2006.01), C12N 15/00 (2006.01), C12P 21/06 (2006.01), C07H 21/04 (2006.01)
Applicants: APPLIED GENETICS INCORPORATED DERMATICS [US/US]; 205 Buffalo Avenue, Freeport, NY 11520 (US)
Inventors: YAROSH, Daniel, B.; (US).
ESTIS, Leonard, F.; (US).
KRAUS, Eliyahu; (US)
Agent: KLEE, Maurice, M.; 1951 Burr Street, Fairfield, CT 06824 (US)
Priority Data:
60/696,256 01.07.2005 US
Title (EN) PRODUCTION OF CPD GLYCOSYLASES
(FR) PRODUCTION DE GLYCOSYLASES CPD
Abstract: front page image
(EN)Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the active proteins can be used in, for example, topical formulations for treatment of photosensitive diseases. Stream mixing can also be used to solubilize inclusion bodies containing proteins other than CPD glycosylases.
(FR)Des formes recombinantes de séquence d'ADN pour glycosylase CPD, comprenant le gène bactériophage T4 denV, sont aptes à s'exprimer en grande quantité. Les glycosylases actives CPD peuvent être récupérées à partir de corps d'inclusion obtenus par haute expression utilisant, notamment, un procédé d'homogénéisation consistant à mélanger un courant. Les protéines actives peuvent servir dans des formulations topiques pour le traitement de maladies photosensibles. Le mélange de courant peut également servir à solubiliser les corps d'inclusion contenant les protéines autres que les glycosylases CPD.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)